Conditions

Fungal Infections

Fungal infections, which are also known as mycoses, occur when a fungal agent manages to pass through the barriers that are set up to protect the body and establishes an infection. Fungal infections can be classified according to the part of the body that is infected. A superficial mycosis is an infection that affects the outer layers of skin and hair. A cutaneous mycosis infects the epidermal layer of the skin, which is slightly deeper than the parts of the skin that are affected by a superficial infection. Cutaneous infections can also invade deeper into the keratinized layers of the nails and hair. A subcutaneous infection occurs even deeper in the body, in the dermis of the skin, the subcutaneous tissues, the muscle and the fascia. A systemic infection affects the organs of the body.

The part of the body that has been infected by the fungus will affect the type of symptoms that are experienced and the severity of the condition. A superficial mycosis is usually less problematic than a systemic one, for example.

Different types of fungal infection are given different names. Common fungal infections are athlete’s foot, thrush and other yeast infections, ringworm, jock itch, valley fever and nail fungus.

Despite the differences between fungal infections, they are all treated in similar ways, by the application of an antifungal drug. In the same way that antibiotics are used to treat different bacterial infections, antifungal drugs can be used to treat infections caused by fungi. In some cases, however, the infection may also be treated with surgery rather than simply with an antifungal agent alone.

Symptoms

The symptoms of fungal infection can vary a great deal depending on the type of infectious agent that is involved and the part of the body that has been affected.
Fungal Infections
Tinea versicolor is a common superficial fungal infection that usually occurs in young patients. It creates small light or reddish brown spots that are mainly found on the back, chest, legs and upper arms. There are two forms of this infection, only one of which causes spots that are visible. Other than the spots, there are usually no symptoms and the infected person remains healthy.

Unlike superficial infections, cutaneous infections can create an immune response in the patient. This can lead to pathologic responses and changes in the affected layers of the skin. Roundworm, for example, presents as round scaly red rings on the skin. Fungal organisms that cause cutaneous infections are known as dermatophytes, while the diseases that they cause are often called tinea or ringworm. Despite the name, ringworm is a condition that is caused by a fungus and not an actual worm. The species of fungus that cause this type of infection are Trichophyton, Epidermophyton and Microsporum.

Types of Infections

Subcutaneous fungal infections are usually chronic conditions. They often begin after the skin has been pierced by an injury of some kind, since this allows infectious fungi to penetrate the skin and establish themselves inside. The treatments for subcutaneous infections are usually more drastic than those for less severe infections.

Systemic fungal infections may be either primary or opportunistic. A primary pathogen infects the body independently of any other medical condition, while an opportunistic pathogen can only cause an infection in a body that has already been weakened by something else. Primary fungal pathogens are most likely to enter the body through the lungs, which is where they generally cause their first infection.

This can then be spread to other organs in the body. Most primary pathogens are dimorphic fungi, which means that there are two different forms in the lifecycle. Opportunistic fungal pathogens can only establish an infection when the defenses of the body have been lowered by some sort of immunosuppressive condition. This could be a disease such as AIDS or a metastatic cancer (one that has spread to multiple parts of the body) or a treatment such as immunosuppressant drugs or antibiotics. Aspergillosis, Candidiasis and Cryptococcosis are all opportunistic fungal infections. Systemic infections are the most serious.

Diagnosis

Many fungal infections cause characteristic symptoms that can be used to make a diagnosis. In some cases, laboratory tests may be needed to rule out any other possible causes of the symptoms and to identify the specific fungus that is responsible for the infection.

Causes

Fungal infections occur when a fungus enters the body and causes an infection. The fungus multiplies within the infected part of the body, and may be able to spread to other body parts. In some cases, the fungus requires some help in order to be able to infect the body. Opportunistic systemic fungal pathogens cannot infect a body unless its immune defenses have already been broken down by another infection or disease, or are being suppressed by a medication that is being taken.

Similarly, some subcutaneous infections can only reach the lower levels of the skin where they can establish an infection when a path has been opened up for them by some sort of injury that has penetrated the skin. Other fungal infections can occur without such help. They simply need to come in contact with the skin, or be breathed into the lungs in order to infect the patient.

Fungi come in a number of different forms. Fungal cells are similar to plant cells, and fungi are comparable to plants. They are neither plants nor animals, however, but form their own separate group, with its own unique characteristics. Fungi do not produce their own energy in the same way as plants, and must therefore find food from other sources. Most fungi break down dead material, but others can infect living organisms.

Major Infections

Fungal infections are named after the species of fungus that causes the infection. The major fungal infections are

  • aspergillosis (caused by Aspergillus)
  • blastomycosis (caused by Blastomyces)
  • candidacies (caused by Candida)
  • coccidioidomycosis (caused by Coccidioides)
  • cryptococcosis (caused by Cryptococcus)
  • histoplasmosis (caused by Histoplasma)
  • paracoccidiomycosis (caused by Paracoccidioides)
  • sporotrichosis (caused by Sporothrix)
  • zygomycosis (caused by Zygomycetes).

Each of these conditions is caused by a specific type of fungus. Some other fungal infections cannot be classified in the same way because they can be the result of a number of different types of fungus: chromoblastomycosis, lobomycosis, mycetoma, onychomycosis, various Tinea diseases, piedra, pityriasis versicolor, otomycosis, phaeohyphomycosis and rhinosporidiosis, as well as a number of infections affecting the eyes, skin, hair and nails.

Tinea infections are the most common type of fungal infection. Athlete’s foot is an example of this type of infection. It affects the feet, causing itchiness and flaky skin. It can also spread to the toenails, causing them to thicken and become discolored.

Candida infections, which are also known as thrush, are also very common. Candida usually lives on the body without causing any problems, but sometimes it can cause an infection of the mouth or the vagina.

Prevention

Many types of fungal infections can usually be prevented by following good hygiene practices. Ensuring that the skin is kept clean and dry can help to prevent fungal infections from affecting the skin. It is also important to wash thoroughly after coming into contact with other people or with animals. Infection can be avoided when using public swimming pools and showers by wearing flip-flops to protect the feet. Regularly cleaning sports clothes can also help to prevent fungal infections.

In order to prevent the development of an internal fungal infection, which could be very serious, antifungal drugs are sometimes prescribed as a preventative measure to patients who are in a high-risk group. Regularly taking this medication can prevent an infection from taking hold. Fluconazole is an example of an antifungal drug that can be used to prevent fungal infections in the body.

Treatments

Fungal infections are treated with a type of drug that is known as an antifungal agent. These may be taken either orally or applied to the skin, depending on the sort of infection that is being treated. Most antifungals work by attacking the cell walls of the infectious fungus. Once these have been damaged, the fungus will die. Antifungal drugs work by discriminating between the cells of the body and those of the fungus, but since there can be similarities between these cell types, the drug may sometimes act on a human cell. This can cause adverse side effects.

There are many different types of antifungal drug. Most of these drugs can be classified into the following categories, although there are also some other topical and systemic drugs that do not fit into one of these groups.

  • allylamines
  • antimetabolites
  • azoles
  • chitin synthase inhibitors
  • glucan synthesis inhibitors
  • polyenes

In order to increase the chances of a drug being successful for the treatment of a particular infection, it is important to choose the right drug to combat that particular condition. Different fungal agents will react differently to particular antifungal drugs. Most fungal infections can be treated by multiple drugs, depending upon which one the doctor believes is most suitable for the individual case.

In the same way as bacteria can develop a resistance to antibiotics, infectious fungi can become resistant to antifungal drugs. When a resistant infection occurs, it may need to be treated with an alternate antifungal drug. It will usually be more difficult to get rid of a fungal infection that has developed some resistance to treatment, since if the first choice drug cannot be used, the second choice drug may not be quite as effective.

Applications of Medicine

Topical application of an antifungal agent, that is application onto the skin in the form of a cream or shampoo, can be used to treat fungal infections of the skin and vagina. Drugs that can be used in this way include amorolfine, miconazole, ketoconazole, griseofulvin and sulconazole. In some cases, an antifungal cream may be used in conjunction with another sort of cream, such as a steroid cream, which can reduce the inflammation as the antifungal cream destroys the infection.

Oral application of antifungal drugs can be in the form of liquids, capsules or tablets. Nystatin and amphotericin are taken by mouth, as either lozenges or liquids, but they cannot be absorbed through the digestive system. Instead, they are used to treat fungal infections of the mouth and the throat. Other oral antifungals do need to be absorbed in order to work in other parts of the body. Antifungal medications that work in this way include terbinafine, which is often used to treat tinea infections in the nails, and fluconazole, which is often used as an alternative to topical treatment for vaginal thrush. It can also be used to treat infections within the body. Both terbinafine and fluconazole are taken in the form of tablets.

In some serious cases, the antifungal drug is delivered in the form of an injection. Injectable antifungals include flucytosine, voriconazole, amphotericin, caspofungin and itraconazole.

Subcutaneous infections may require surgical treatment in combination with antifungal drugs. For example, the infected tissue may be removed in a process known as debridement.

Traditional Remedies

There are many traditional cures and remedies that have been used to treat fungal infections. Some of these have some basis in fact, but others are ineffective. While antifungal drugs are usually effective, unless the fungus has developed a resistance to them, these traditional remedies are usually unable to eradicate a fungal infection. They may help to ameliorate the symptoms of the infection, however, and some remedies can help to keep fungal infections at bay.

A scientific study conducted in 1996 found that a number of essential oils and other substances had some antifungal properties. These included allicin (produced from crushed garlic), citronella oil (produced from the leaves of lemongrass), tea tree oil, coconut oil, zinc (when taken as supplements or eaten in foods such as chickpeas and pumpkin seeds), selenium (in supplements or in foods such as Brazil nuts), iodine, orange oil, Neem seed oil, patchouli, lemon myrtle and palmarosa oil.

More recently, a 2009 study discovered that certain chemicals which are found in carnivorous plants such as the Venus flytrap have antifungal properties. These substances could be used in the future to create new antifungal treatments for fungal infections that have become resistant to other therapies.

It may also be possible to help the body to fight off a fungal infection by taking supplements such as vitamins that are believed to be able to give a boost to the immune system. There is no scientific proof that this type of remedy is effective, however.

Prognosis

The prognosis is good for many fungal infections. They can be eradicated with antifungal drugs and will cause no long-term problems. Other fungal infections can cause serious damage, and may even result in the death of the patient. Systemic infections are the most damaging, and the most difficult to cure.

Fungal infections of the nails, skin, mouth and vagina are very common. They are also easily treatable and are usually resolved without causing any serious problems or spreading to other parts of the body.

More serious internal infections usually occur when the immune system is weakened, and they can be much more harmful. They are also much more difficult to treat successfully. In some cases, systemic fungal infections can be life threatening. Systemic infections can also lead to complications. Cryptococcosis, for example, can result in meningitis.

Complications

Antifungal drugs may cause certain side effects. The possible adverse reactions depend upon the specific drug that is being taken. Antifungal shampoos and creams are the safest forms of treatment and very rarely cause any problems. Some people who are particularly sensitive may develop irritation in the area where the medication has been applied. This is most common with creams that are used for vaginal infections. Oral medications are also generally harmless and can usually be bought over the counter because of this. In rare cases, side effects such as problems with the liver or changes to the levels of estrogen in the body may occur after taking this type of medication. Injected medications can have more serious side effects, and are only used in the most serious cases.

Some people may be allergic to certain antifungal drugs. Azole antifungal drugs have resulted in cases of anaphylactic shock, for example. Antifungal drugs may also interact harmfully with other types of medication. Azole antifungals produce adverse reactions when mixed with immunosuppressants, chemotherapy drugs, calcium channel blockers, tricyclic antidepressants, SSRIs, benzodiazapenes and macrolides.

If a fungal infection cannot be cured then it can continue to cause damage to the body and may spread. Systemic fungal infections can be particularly harmful if they are not eradicated, and may even be fatal.

Cost

There is wide variation in the costs of treatments for fungal infections, since the types of treatments that may be necessary can vary enormously. Some topical treatments for mild infections of the skin can be bought over the counter at a drug store for well under $10. Other types of treatment can cost over $200. There are also various antifungal drugs that fall in between these prices. The most expensive antifungal drugs can cost as much as $600, although these costly drugs will only be required in the most serious cases.

If surgical treatment is required, then this will significantly add to the cost.

The essential oils and other traditional remedies for fungal infections are fairly cheap. They can usually be bought for less than $10 at a health food store or other specialist stockist.

Resources

National Institute of Health

Mayo Clinic

WebMD

Conditions

Morning Sickness

Overview of Morning Sickness

Morning sickness is a condition which occurs during pregnancy that affects approximately more than half of all pregnant women, but it may also be experienced by women using hormonal contraception or hormone replacement therapy. Usually prominent during the early hours of the morning, morning sickness can occur during any part of the day including during the night.
Herbal Morning Sickness Remedies
This condition may be experienced only as mild nausea, or it may cause actual vomiting. In only about 1% of all pregnancies, vomiting may become severe enough to cause dehydration, weight loss, alkalosis (a condition in which the pH of the blood is elevated beyond normal and results in hypoventilation as an attempt to balance the pH), and hypokalemia (a condition in which the concentration of potassium (K+) in the blood is low which may result in elevated blood pressure, cardiac arrhythmias, and/or muscle weakness); this severe form of morning sickness is known as hyperemesis gravidarum.

Morning sickness may be one of the earliest signs that a woman may be expecting a child and usually begins around the 6th week of pregnancy, and it seems to cease around the 12th week of pregnancy for most pregnant women which marks the end of the first trimester and the beginning of the second trimester of pregnancy. However, morning sickness may continue throughout the entire pregnancy for some women.

Alternative names of Morning Sickness

  • Nausea gravidarum
  • Nausea
  • Vomiting of pregnancy
  • Emesis gravidarum
  • NVP
  • Pregnancy sickness

Symptoms of Morning Sickness

Nausea during pregnancy which may or may not be accompanied by vomiting.

Causes of Morning Sickness

  • Some women are sensitive to the hundredfold increase in the hormone estrogen circulating in their blood.
  • Progesterone also increases which relaxes the smooth muscles of the uterus as well as the smooth muscles of the stomach and intestines resulting in excessive amounts of stomach acids which leads to heartburn, or gastrointestinal reflux.
  • Hypoglycemia, or low blood sugar, may be to blame for nausea and/or vomiting in pregnancy due to the placenta taking energy from the expectant mother.
  • A sudden increase in the pregnancy hormone, HCG (human chorionic gonadotropin), may inevitably cause nausea.
  • Increases in the hormone cholecystokinin causes slowed digestion in order for more efficient nutrient absorption to take place both for the mother as well as the growing fetus.
  • Perhaps as a built-in defense mechanism against harmful substances, pregnant women tend to experience an increase in sensitivity to odors, which therefore over stimulates the nausea center of the brain.

Risk Factors of Morning Sickness

  • A pregnant woman may be at risk for pregnancy-related nausea if she has ever experienced any of the following prior to the current pregnancy: motion sickness, migraines, sensitivity to certain smells or tastes, sensitivity to estrogen in birth control pills, or she has experienced morning sickness during a previous pregnancy
  • An expectant woman may also be at risk for morning sickness if she is pregnant with more than one fetus.

Complications of Morning Sickness

Complications that could jeopardize the pregnancy may arise as a result of more severe morning sickness, hyperemesis gravidarum, and include the following:

  • Dehydration
  • Malnutrition
  • Weight loss
  • Alkalosis
  • Hypokalemia
  • Acid reflux
  • High blood pressure
  • Hypoventilation
  • Muscle weakness
  • Cardiac arrhythmias

Tips for lessening nausea and avoiding vomiting associated with morning sickness:

  • Consume foods that are high in carbs but low in fat.
  • Salty foods such as pickles, pretzels, and saltines as well as foods containing ginger can help in lessening and/or preventing morning sickness.
  • Avoid greasy, spicy and fatty foods which help create more stomach acid.
  • Eat six small meals rather than three large meals per day.
  • Have some saltines handy on your nightstand to nibble on 15 minutes before getting out of bed in the morning.
  • Avoid an empty stomach which may aggravate nausea.
  • Drink water and other liquids 30-45 minutes before or after meals.
  • Sip water and/or ginger ale throughout the day to avoid an empty stomach and/or dehydration.
  • Sucking on something hard such as candy or ice chips or ice pops may be helpful.
  • Avoid known nausea triggers such as foods or smells that seem to aggravate your nausea.
  • Expose yourself to as much fresh air as possible versus stale indoor air.
  • Take your prenatal vitamins at night with a snack to avoid queasiness brought on by the vitamins.
  • Expose yourself to the smell of freshly cut citrus fruits such as lemons.
  • Accommodate food cravings (things you want) and aversions (things that aggravate your morning sickness) when possible.
  • Pregnant women tend to crave or get nauseated by things typically because their bodies are telling them what they need or what they need to avoid in order to have a healthy pregnancy outcome.
  • Consume fruits and vegetables with a high water concentration such as tomatoes, melons, citrus fruits, strawberries, leafy vegetables, and grapes.
  • Try the BRATT diet to keep your stomach settled. The BRATT diet is simply made up of bananas, rice, applesauce, toast and tea.
  • If the smell of food being cooked aggravates your nausea, have a loved one cook for you, and make sure there is plenty of ventilation such as having a fan on and/or windows open.
  • Rest as often as humanly possible!
  • Avoid getting overheated which exacerbates pregnancy nausea.
  • Try to work in some light exercise such as walking and/or swimming, but don’t over do it.
  • Avoid laying down immediately after eating. Try to allow 2-3 hours after eating to avoid stomach upset caused from acid.

Testing and diagnosis for Morning Sickness

There are no specific tests available to diagnosis morning sickness in itself due to the fact that morning sickness is merely a symptom of pregnancy. On that note, a positive pregnancy test may tell a woman the cause of the nausea and/or vomiting she has been experiencing.

However, sever morning sickness known as hyperemesis gravidarum, or HEG, may require further testing in order to rule out other complications in the pregnancy.

Further testing may include the following:

  • Amylase
  • Blood calcium level
  • Serum electrolytes, which can show low potassium or sodium levels in blood. Low levels can mean dehydration or acid-base imbalance.
  • Hematocrit, part of a blood count, which may become high due to dehydration
  • Liver enzymes and bilirubin
  • Urinalysis for ketones and specific gravity. Ketones are a sign of starvation. Specific gravity can show dehydration.
  • An ultrasound may also be done to check the condition of the baby and the womb.
  • If a woman has abdominal pain or vomits blood, the doctor may do an endoscopy. This is a test where a small tube is passed through a woman’s mouth and throat down to her stomach. The tube has a light at the end, which helps the doctor to look for problems in the stomach.
  • Serum for hepatitis testing
  • Liver function tests
  • Ultrasound to look at gallbladder
  • Urinalysis and culture to test for bacteria
  • Ultrasound to look for twins or a tumorous growth of the placenta

Treatment Options for Morning Sickness

Herbal & Home Remedies

  • Drink a few teaspoons of wheat germ dissolved in warm milk every hour until the nausea subsides.
  • Take 1 tablespoon of apple cider vinegar mixed with 1 tablespoon of honey in cold water before bed.
  • Suck a piece of peeled ginger root.
  • Drink red raspberry leaf tea.
  • Drink peppermint or spearmint tea.
  • Drink squaw vine tea.
  • Drink ginger tea. Make the tea by boiling some ginger root in water then straining it. Finally, add honey to taste.
  • Rear motion sickness bands on your wrists where pressure points which control nausea are located.
  • Put three drops of lavender essential oil and one of peppermint in a diffuser or humidifier to scent the air.
  • Place a cool lavender scented compress on your forehead and a warm lavender compress over your rib cage.
  • Have a loved one massage you with a soothing chamomile massage oil.
  • Snack on ginger snap cookies made with real ginger.

Pharmaceutical Remedies

Non-prescription morning sickness remedies include the following:

  • Emetrol is the only non-prescription nausea medication that’s considered safe during pregnancy.
  • For women whose nausea and vomiting is triggered by acid, reflux medications such as Zantac or Pepcid may work.
  • According to the FDA, the combination of Doxylamine and vitamin B6 is considered safe and effective for nausea and vomiting associated with pregnancy.
  • Doxylamine is available as a sleeping pill under the brand name Unisom Nighttime Sleep-Aid, not Maximum Strength Unisom Sleep Gels which is an entirely different product. Vitamin B6 may be located in the vitamin section of your local grocery store or pharmacy.

Prescription Remedies

Compazine

Possible side effects:

  • Abnormal muscle rigidity
  • secretion of milk
  • sugar in urine
  • abnormalities of posture and movement
  • agitation
  • anemia
  • appetite changes
  • asthma
  • blurred vision
  • constipation
  • convulsions
  • difficulty swallowing
  • discolored skin tone
  • dizziness
  • drooling
  • drowsiness
  • dry mouth
  • exaggerated reflexes
  • fever

You should never suddenly stop taking Compazine, due to adverse effects such as a change in appetite, dizziness, nausea, vomiting, and tremors. When discontinuing this drug, it is important to follow your doctor’s instructions closely. Your ability to drive a car or operate heavy machinery may be impaired when taking this drug, so take extreme caution when participating in any activities that require full alertness. Take caution when outdoors due to sunlight sensitivity related to the use of Compazine. Avoid direct sunlight and use sun block and wear protective clothing including sunglasses. Also, beware that Compazine may interfere with your ability to shed extra heat, so take caution in hot weather.
Morning Sickness Cures
Be sure your doctor is aware of any drug you are taking. Compazine may interact with the following drugs: Anti-seizure drugs such as Dilantin and Tegretol, Anticoagulants such as Coumadin, Guanethidine (Ismelin), Lithium (Lithobid, Eskalith), Narcotic painkillers such as Demerol and Tylenol
with Codeine, Central nervous system depressants such as Xanax, Valium, Seconal, and Halcion Propranolol, and Thiazide diuretics such as Dyazide

Tigan

Possible side effects:

  • Hypersensitivity reactions
  • Parkinson’s-like symptoms
  • blood dyscrasias
  • blurred vision
  • coma
  • convulsions
  • depression of mood
  • diarrhea
  • disorientation
  • dizziness
  • drowsiness
  • headache
  • jaundice
  • muscle cramps

Tigan is contraindicated and should not be used in patients with known hypersensitivity to trimethobenzamide. Stop using this drug and tell your doctor immediately if any of these serious side effects occur.

Conclusion

Once more, morning sickness may range anywhere from mild nausea to severe vomiting. Before using any remedy, whether it be a herbal/home remedy or a medication, always first consult with your physician. Home remedies should be your first line of defense for morning sickness due to adverse effects related to the use of medications. If all else fails, your doctor can help you decide on the best treatment option for your morning sickness. Remember, the healthier Mom is the healthier the baby will be!

Conditions

Pneumonia

What Is Pneumonia?

Pneumonia, rather than being a specific disease, is something of a catch-all term to describe respiratory distress brought on by a number of different causes, all of which have the same end result. The lungs experience potentially hazardous levels of inflammation, usually brought on by bacterial, viral or fungal infection. In some cases, chemicals or accidentally inhaled fluids may also lead to pneumonia.
pneumonia causes
No matter what the origin may be, pneumonia is characterized by inflammation of the alveoli. The alveoli are microscopic air sacs within the sponge-like tissue of the lungs. Infections or irritants can cause these sacs to become swollen and blocked with fluid or pus. When this happens, breathing is restricted and the body becomes starved for adequate oxygen. Without treatment, pneumonia can worsen significantly, necessitating hospitalization and even causing death. Of the more than three million people who will contract pneumonia, 150,000 will die. That is why early detection, varied treatment options and ultimately, preventative care are important

Signs and Symptoms

Symptoms of pneumonia can progress from very mild to life threatening. It is often mistaken for the flu until the illness worsens to a serious health threat. Most commonly, you’ll have a persistent, phlegm-producing cough in which blood may be present, and shortness of breath. Many people experience chills, sweats and fever, headaches and muscle pain. In severe cases, you may even feel nausea and diarrhea set in.

Because the term “pneumonia” describes a condition that can have a variety of origins the exact combination of symptoms will vary from one case to the next. Your individual health profile is also a pivotal determining factor in how pneumonia symptoms will present themselves.

Who Gets Pneumonia?

In a given year, over 3 million people will get pneumonia with fifty percent of those infected needing hospitalization. Years ago, more than a third of those who contracted pneumonia would die from it. Thanks to the introduction of modern antibiotics, the mortality rate for pneumonia has gone down to 5%, with many people capable of receiving treatment at home.

Those at greatest risk for getting pneumonia are:

The Elderly

People over the age of 65 are at much greater risk. In the elderly population, pneumonia often exhibits much subtler symptoms than in teens and adults. Therefore, it is extremely important to see a doctor if you notice any sings of infection.

Young children

Young children with still-developing bodies may not yet have acquired the full complement of antibodies their immune systems need to fight infection. Parents should be particularly watchful for early signs if their child has a history of respiratory conditions like as asthma. As with the elderly, symptoms of pneumonia in children tend to be milder, and therefore risk being mistaken for flu.

People whose immune systems have been weakened by illness

If your immune system has been compromised by an illness, whether chronic or acute, opportunistic varieties of pneumonia can be a threat. Sources of immunological distress may include things like a recent illness, chronic obstructive pulmonary disease (C.O.P.D.), cardiovascular disease, emphysema, diabetes, HIV/AIDS, extreme stress, or even prescription medicines. All of these conditions tax the immune system, leaving your immune system too depleted to resist further infection.

Individuals taking immunosuppressant medicines

Immunosuppressive drugs are prescribed for people who have had organ and tissue transplants and those with autoimmune disorders such as psoriasis, ulcerative colitis (Crohn’s disease), arthritis and multiple sclerosis. All of these are characterized by the body’s immune system attacking its own tissues or cells.

Organ transplant recipients

In the case of an organ transplant, the body may mistakenly react to the new organ as though it is a hostile invader. This erroneous response may cause the rejection of the transplanted organ. By blocking these reactions in the immune system, immunosuppressive drugs protect the new organ, greatly reducing the likelihood of rejection and making such preventative treatment essential to the long-term survival of a transplant recipient.

Autoimmune Disease

An autoimmune disorder is a malfunction of the immune system in which the body attacks its own tissues, or hyper-reacts to substances with which you come into contact. Chronic autoimmune disorders like rheumatoid arthritis and multiple sclerosis are usually crippling and can even be fatal. Dulling the activity of the immune system serves to protect the body from dysfunctional internal responses while also reducing the discomfort. Sadly, the almost universal trade off in using such drugs is that they cause increased vulnerability to infections.

People who have recently undergone chemotherapy

Chemotherapy targets cells in the body that multiply rapidly. However, it does so indiscriminately, meaning that non-cancerous cells are also harmed. While this is clearly ideal for halting the growth of fast-growing tumors, it also reduces the number of white blood cells available in the blood stream and lymphatic system. White blood cells, also called leukocytes, serve immunological functions that range from protecting the body from bacteria, fungi and parasites, to limiting inflammation. Since all of these factors commonly precede pneumonia, the additional vulnerability caused by chemotherapy requires vigilance by both patient and physician.

Smoking and Alcohol Abuse

Smoking causes severe damage to the cilia within the nasal cavity and bronchial passages. Cilia are microscopic hairs that act as filters for the airways. They prevent dust particles and other airborne irritants from making their way into the delicate lungs. By beating in a wave-like manner, they gently move natural secretions and irritants out of the airway before they can cause harm. Smoking causes paralysis of these important filtration devices, allowing secretions to build up and block the airways. If these secretions contain bacteria or other infectious agents, they can cause pneumonia.

Alcohol can adversely affect your gag reflex, preventing your body from expelling irritants to the throat, the shared pathway of the digestive and respiratory systems. Alcohol also slows the activity of white blood cells.

Additional Risk Factors

Hospitalization in an Intensive Care Unit

Patients in intensive care units of their hospital are already in a state of acute physical and often, emotional distress that can have a negative effect on their immunity to pathogens. Moreover, should they be placed on artificial ventilation, their risk of getting pneumonia rises significantly. The breathing tube inserted through the mouth bypasses much of the upper respiratory tract where many of the respiratory system’s defense mechanisms reside. It prevents the patient from coughing and can also cause the contents of the stomach to back up and be inhaled accidentally. When these contents contain pathogens or irritate the tissue of the lungs, pneumonia can develop.
pneumonia symptoms

Surgery or Traumatic Injury

People who have recently had surgery or any kind of traumatic injury are at increased risk. Their lack of mobility, especially if they have to lie on their back, can make it difficult to cough end expel accumulated mucus from the lungs. Immobility can also impede the proper circulation of lymph through the body. Lymph is the body’s natural cleaning system. It cleans dead cells and pathogens from the bloodstream and tissues. When its circulation is not optimal, your resistance to infection is also reduced.

These issues, as well as the increased presence of antibiotic-resistant pathogens in hospitals may explain why pneumonia acquired during a hospital stay tends to be more severe than other kinds.

Inhaling corticosteriods for more than 24 weeks

Corticosteroids are prescribed as a treatment for chronic obstructive pulmonary disease. However, according to research published by Johns Hopkins in the Journal of the American Medical Association, they increase the risk of pneumonia by as much as 46%. Although the exact reason is not certain, researchers at the university speculate that inhaled corticosteroids suppress the immune system.

Exposure to Chemicals or Environmental Pollutants

Those who work in the industrial, agricultural, military or building industries may be exposed to chemicals which cause inflammation within the lungs, making it hard for your body to keep them clear. Living in areas with high levels of pollution can also increase the risk of getting pneumonia.

Ethnicity

The rate of pneumonia infection is three times higher in African Americans than in Caucasians. In Native American populations, that number jumps up to being 5-10 times that of whites. According to the Center for Disease Control, the mortality rate for Native American infants with pneumonia is double that of the general U.S. population. For this reason, many contemporary allopathic medical practitioners recommend vaccinations for those whose ethnicity places them in a higher risk category.

Causes and Types of Pneumonia

Pathogens

The term pathogen refers to any cause of disease, but most commonly refers to infectious agents. These include bacteria, viruses and fungi. Certain opportunistic infectious organisms can cause severe, even deadly, forms of pneumonia and can affect even healthy people. Examples include the avian flu virus (H1N1 influenza) and SARS (severe acute respiratory syndrome), tuberculosis, anthrax, and plague.

Community-acquired pneumonia

This refers to pneumonia acquired in places people frequent in their everyday lives. Places like your child’s nursery school, your gym, public transportation and your office can be hosts to two types of bacteria which cause pneumonia. The first, streptococcus pneumoniae is the most common cause of pneumonia. The other, mycoplasma pneumoniae causes the mild form of pneumonia which is usually referred to as “walking pneumonia.”

Hospital-acquired pneumonia

Pneumonia contracted during a hospital stay, called nosocomial pneumonia, is usually more serious than other varieties. Hospital-acquired pneumonia is only diagnosed if pneumonia symptoms present themselves at least 48 hours after you are admitted. One subtype within this category is post-operative pneumonia, most common in patients over 70, who have undergone chest or abdominal surgeries. Another subcategory is health-care associated pneumonia, found in people whose health requires them to go to dialysis centers or chronic care clinics where medications are administered by intravenous drip (I.V.).

Medical Tests and Diagnosis

When to Consult a Physician

Pneumonia can be life threatening. If you suspect that you may have it, it is very important to see a qualified physician before your symptoms become severe. If you have a history of respiratory conditions, it is even more essential that you seek out medical expertise right away, since the early stage symptoms can be quite mild, and easily mistaken for a cold or flu. If you are recovering from a cold or flu which suddenly becomes worse, you should see your doctor to rule out pneumonia. If you are experiencing an inexplicable fever over 102ºF, especially if it is accompanied by chills and sweating, and if you have an ongoing cough or shortness of breath, it is time to enlist professional assistance.

Elderly adults, young children, and all those in high risk populations need quick attention since their conditions can progress rapidly from mild to dangerous.

Diagnosis

Diagnosis of pneumonia is made based on several factors. First your physician will consider your health history, particularly whether you have a history of respiratory illnesses. Next, he or she will use a stethoscope to listen to your lungs. Crunchy or bubbly breathing sounds may indicate the presence of fluid accumulation in the lungs. If your doctor detects them, a chest x-ray may be ordered. The x-ray images can confirm with certainty whether you have pneumonia while also allowing your doctor to pinpoint the exact location of the infection. Sometimes, your doctor may also take blood and mucus samples. Analysis of your blood will tell your physician whether your white blood cell count is healthy, while mucus specimens will reveal the exact pathogen behind the infection. Knowing whether the origin of pneumonia was a specific bacterial infection or virus allows your doctor to treat you more quickly and accurately.

How is pneumonia treated?

Treatment of pneumonia is determined by matching the origin of the illness to the proper medication, or other means of healing.

Bacterial

Bacterial infections are treated with antibiotics.

Viral

If a virus caused the infection, your doctor might prescribe antiviral medication. However, it is much more common for no drugs, but plenty of rest and fluids to be the recommended.

Fungal

If your infection was caused by fungi, antifungal medications are available.

It is essential that you take medications exactly the manner your doctor has prescribed. Use the entire prescription to ensure that no remnants of the illness remain in your system.

Side Effects

Side effects from antibiotics, antiviral and antifungal drugs can include stomach upset, anemia, headaches, rashes, kidney damage and liver damage.

Alternative Treatments

Because pneumonia can be life threatening, you should seek the advice of a medical doctor before using alternative care exclusively. Alternative treatments should be complementary to medical care, rather than replacing it completely. In cases when no pharmaceutical prescription is offered, alternative remedies can offer an excellent source of added support and comfort as your body recovers. For individuals who are at a higher risk of getting pneumonia, alternative therapies like herbs and acupuncture are excellent preventative tools.

Acupuncture

Acupuncture uses precise placement of nearly invisible needles to stimulate and balance the flow of bio-electric energy through the body. Its effects bolster immunity, strengthen your lungs and clear excess mucus from your body. Acupuncture practitioners typically have a master’s degree in their art and will do a very detailed exam to determine the best way to assist you. Clinical studies continue to find evidence which supports acupuncture as effective and gentle, and its acceptance in the medical community continues to grow.

Side Effects

Rare. Acupuncture may cause minor, temporary tenderness at the site of needle insertion. Post-treatment, patients may be lightheaded.

Costs

$60-$125 per treatment

Garlic

Garlic is one of the few treatments proven in clinical studies to have an antiviral effect. Since doctors frequently do not prescribe any pharmaceutical medications for pneumonia of viral origin, garlic may be a valuable source of additional support. Herbalists also use garlic to reduce fever and support the cardiovascular system. Garlic supplements should be taken according to a manufacturer’s recommended dosage or the advice of a qualified herbalist. It is useful as a preventative agent as well as a home remedy during an active illness.

Side Effects

Garlic users may notice an odor in the sweat or breath. Garlic may have a very mild blood thinning effect, so excessive intake should be avoided in those who have very low blood pressure or clotting issues.

Cost

$7-$10

Lobelia

Lobelia is a bronchial dilator, meaning it dilates or opens the bronchial passages to ease restricted breathing. It is available in tincture form, with a recommended initial dosage of 10 drops per day.

Side effects

Lobelia is a strong emetic, meaning it can cause nausea in sensitive individuals.

Cost

$10-25

Lungwort

Lungwort is an expectorant, meaning that it clears mucus. In Chinese medicine, it is also considered an emollient, making it a potentially soothing substance. It is known for its gentleness, making it safe even for children. In widely published medical studies, it is praised for potent antibacterial action against strep, staph, and other organisms associated with tuberculosis and pneumonia. When taken in tincture form, 2-4 droppers per day are recommended.

Side effects

None

Cost

$10-25

Preventing Pneumonia

Prevention is the best avenue for avoiding the complications of pneumonia. With more and more treatment resistant strains of bacteria and viruses emerging in recent times, prevention is your most effective line of defense. Any means of strengthening your body’s natural resistance to infection are invaluable. If you have risk factors for pneumonia, like asthma, G.E.R.D., or smoking addiction, resolving those issues will also reduce your vulnerability to infection. For those in high-risk categories, such as the elderly and young children, vaccination may be recommended.

Conditions

Poison Ivy

Poison ivy is notorious for causing skin irritation and rashes. When this happens, it is called allergic contact dermatitis. A person will generally experience this because poison ivy has an irritant in it that humans are sensitive to, and it is also found in other kinds of toxic plants, such as poison sumac or poison oak. The irritant that is present in these toxic plants is an oily kind of resin that is called urushiol. This is what causes rashes and irritates the skin in the process.
Natural Poison Ivy Cures
Though a person will certainly be bothered with the itchiness that occurs from a rash from poison ivy, there is the peace of mind that a rash from poison ivy, poison sumac or poison oak is really never very serious. There are several methods that can be done at home to relieve the symptoms of the dermatitis until it goes away on its own.

Symptoms

A person should suspect that poison ivy is to blame if any of the following symptoms are present:

  • Redness
  • Itching
  • Swelling
  • Blisters

Due to the way that a plant generally brushes against a person’s skin, the rash will probably appear to be in a straight line. However, it is possible for the rash to be more widespread if a person brushes against any kind of pet fur or clothing that happens to have urushiol coated on it.

After coming into contact with urushiol, a reaction will develop about 48 hours later, at the most. It has the potential to last upwards of two months, depending. How severe the dermatitis rash is ultimately depends on how much urushiol was involved in the contact.

In cases with more severity involved, there may be other rashes that appear a few days after a person was first exposed to the resin, and it will probably look as if though it is beginning to spread. However, this is probably not the case; it is more probable that the skin simply absorbed the resin at a stranger rate than normal.

The skin will not be affected unless it comes in direct contact with urushiol from the plant. If a person scratches the blisters and they pop, the rash will not spread from touching the fluid. However, if they are dirty fingernails with germs underneath, there is the risk of another bacterial infection.

When to See a Doctor

If any of the following instances occur, it is recommended to see a medical professional for assistance:

  • The reaction is widespread or otherwise severe.
  • The rash is located on a sensitive area, such as the mouth, eyes or genitals.
  • The blisters are beginning to seep pus.
  • A fever begins to develop of over 100 degrees Fahrenheit, or 37.8 degrees Celsius.
  • The rash remains after several weeks.

Causes

The three main causes of developing a dermatitis rash and the itchiness that follows include poison ivy, poison oak, as well as poison sumac.

  1. Poison ivy is a plant that looks like weeds and is actually very common. This kind of green will usually grow as a tall, thick vine against a tree, a bush or a regular plant. There is usually a triplet of leaflets to every stem. Some might have a toothy, jagged appearance to them and some will have edges that are smoother than that. When the seasons change, the leaves might change their color to red, orange or yellow. It is possible for them to show little flowers that are green or berries that are green and white.
  2. Similar to poison ivy, there may be triplets of leaflets to every stem of poison oak, which might grow on a plant or as a bush. The leaves look quite like oak leaves and might include some berries which are yellow and white.
  3. Poison sumac as two different rows of leaves growing on each stem, with one at the top. It might grow as a small tree or look like a bush.

No matter what the plant, urushiol, the oily resin, is the cause of irritation in all of them. Even if the smallest amount of the resin touches the skin, it may cause a reaction. This is due to the fact that the resin does not dry and is a very sticky substance, meaning that it has no difficulty affixing itself to pet fur, tools, skin, equipment or clothing.

It is possible to get a poison ivy rash from any of the following instances:

  • Direct touch. When a person directly touches the berries, the leaves, the roots or the stems of a vine, plant or a shrub, there might be a sensitive reaction.
  • Resin remaining on the skin. If the resin gets on the skin by accident and is rubbed in, there may be a sensitive reaction. To illustrate, if a person walks through poison ivy leaves and touches their shoes, it is possible for the resin to get transferred to the hands, from which it may transfer elsewhere, such as the face, depending on what the person touched or rubbed after that.
  • Resin on an object. If a person touches resin that was on firewood, clothing or other items, they are at risk of developing a sensitive reaction. Pets are not typically affected by the resin but a person who pets the animal while there is resin on the fur may develop a rash. It is possible for the resin to retain is allergenic state for several years, and this is especially true if it remains in a dry environment. For example, if a jacket is contaminated and put into a closet without having been washed, it might still cause a reaction if a person touches it when taking it out a year later.
  • Inhaling the smoke of burned sumac, oak or ivy plants. The resin in the plants are still present in the smoke when it burns, and it has the potential risk of injuring the nasal passages and the eyes.

When a person gets a rash from poison ivy, it is not contagious in itself. This is because the blister fluid does not have the resin and it will not cause a rash to spread. Likewise, one person cannot contract a rash from an infected person unless that person has resin remaining on their clothing and the first person comes into direct contact with it.

Complications

If a person has dirty fingernails and scratches a blistering rash from poison ivy, it can cause a bacterial infection to develop. If this occurs, it may result in the blisters oozing pus. It is necessary to see a medical professional in the event that this occurs, since treatment for such an infection will normally involve antibiotics.

Preparing for an Appointment

In the event that a rash results from poison ivy, there will probably be no need to see a medical professional for any kind of treatment. However, if the rash remains after several weeks or there seems to be pus coming out from the blisters, then an infected person will benefit from a trip to the doctor. It is possible that a person may be redirected to a dermatologist, whose specialties lie with disorders of the skin, but try the primary physician first.
Poison Ivy Remedies
Appointments have a tendency to be brief due to time constraints, and there is plenty of ground to cover, so it is wise to make sure that all preparations are made beforehand. This section intends to showcase some of the best ways for a person to be fully prepared for their time spent at the doctor’s office, as well as what they can come to expect from the visit.

What Can Be Done

  • Get a notepad and write down all of the symptoms that have been occurring, even if they seem to not be directly related to the reason for having scheduled the visit.
  • Write down all of the information that will be handy to have, such as how much time has been spent in the outdoors, what vacations were recently taken, if a person has been landscaping, gardening or hiking.
  • Write down any and all vitamins, supplements and medications that are currently being taken, and write down the typical dosage that is taken.
  • Write down all desired questions.

The time spent at the appointment will be limited, so it is best to prepare some questions in advance to reserve time to cover other points. For a patient suffering from a poison ivy rash, some of these questions may be beneficial to ask:

  • What is likely causing these symptoms?
  • Are there any other potential reasons?
  • Will there be any tests?
  • How long until this rash goes away?
  • Is it safe to scratch?
  • Can scratching spread the rash?
  • Can the blister fluid spread the rash?
  • What kind of treatment is there and which comes recommended?
  • Does this treatment come with any side effects?
  • How can the itching be brought under control?
  • How can this be prevented?

What to Expect

The doctor will probably also have a few questions to ask, as well, such as:

  • When the symptoms begin to appear?
  • Have any similar rashes occurred before?
  • Has the outdoors been visited recently?
  • What kind of treatment has already been attempted?

What to Do in the Meantime
Poison ivy rashes will go away in time. However, it can be difficult trying to deal with the itching. Some of the following steps can be done to help alleviate the problem:

  • Use some over the counter corticosteroid cream during the initial days.
  • Use calamine lotion.
  • Take diphenhydramine (Benadryl, others) or any other oral antihistamine that will help aid sleep.
  • Soak in a bath with cool water and either baking soda or some kind of colloidal oatmeal substance, like Aveeno.
  • For half an hour several times each day, take a cool and wet object and compress it to the rash.

Tests and Diagnosis

More often than not, a rash from poison ivy does not require any further medical assistance. However, in the event that an appointment is made, the doctor will be able to make a diagnosis simply from looking at the rash. There is no need to perform any additional tests.

Treatments and Drugs

Most treatments for poison ivy involve methods to perform at home, with the rash giving away and disappearing within two to four weeks. During that time period, it is possible to use different remedies to help relieve the itching and other symptoms. These may include oatmeal baths, cool compresses and some anti-itch over the counter medications.

Prednisone or some other oral corticosteroid may be prescribed by a doctor in the event that many blisters appear or the rash is wide in location. Other treatments may include an oral antibiotic prescriptions in the event that the site of the rash develops some kind of bacterial infection.

Lifestyle and Home Remedies

After a rash has come to fruition, some of the following remedies have been known to alleviate the swelling and the itching:

  • Calamine lotion
  • Low potency over the counter corticosteroid creams, including hydrocortisone, which are then applied two to four times each day.
  • Diphenhydraine (Benadryl, others), or some other kind of oral histamine, which are known to help aid sleeping
  • Half hour long cool and wet compresses on the site of the rash
  • Tub soaks with cool water and baking soda or over the counter colloidal oatmeal substance, such as Aveeno.

Alternative Medicine

Outside of the measures that can be done at home, such as taking a bath with some oatmeal, there are other methods that people tend to seek out in order to relieve their symptoms that arise due to coming into contact with sumac, ivy or oak. Some attempted medicine includes:

  • Jewelweed. Though a study found it was not effective, it was once used by Native Americans in an attempt to relieve poison ivy symptoms.
  • Bovine cartilage cream, with five percent concentration. Studies have shown that if this kind of cream is used on a daily basis, the poison ivy rash can disappear in less than two weeks.
  • Deodorants with aluminum ahlorohydrate. When this deodorant is used prior to going outdoors, it can effectively lead to the prevention of irritated skin when coming into contact with poison ivy resin. However, it is still a good idea to fully wash any clothes and skin in the event that contact may have been made.

Prevention

Many people remember the phrase “leaves of three, let them be,” and it is good that they remember such a thing. This is because many toxic plants, poison ivy included, have a triplet of leaflets on each of their stems, and avoiding contact with them is the best way that a person can prevent from catching an allergic reaction.

There is plenty of advice to follow with regards to avoid rashes:

  • Make sure to learn and fully be able to identify what poison sumac, poison oak and poison ivy look like. Learn the characteristics of each leaf and where they are most likely to be found.
  • Be careful while outside. It is possible to be exposed to poison ivy while hiking, so try to keep on pathways that are clear. Pitch the tent while camping in a clear area without poisonous plants. Do not let pets run through the woods so that they do not pick up the resin from the plants that can be touched. Give the pet a bath with long rubber gloves if it is believed he or she came into contact with resin.
  • Use herbicide to destroy any poison ivy that is growing in the backyard using long rubber gloves. However, it is important to note that even a dead plant can cause a reaction on skin, so remember to wash both the hands and the gloves vigorously. Do not burn any of the plants when they are pulled out, because the resin will remain in the smoke and have the potential to injure the nostrils or the eyes.
  • If anything should get contaminated or is believed to be, wash it. It is possible to protect the skin by wearing shoes, long socks, long pants and gloves, but if it is believed that these clothes have come into direct contact with the resin in poison ivy, immediately wash them with detergent, preferably in a washing machine. Carefully handle the clothes so the resin does not transfer to appliances, furniture or rugs.
  • Wash any and all items that might be contaminated as well, including jewelry, garden tools, shoes and their shoelaces or outdoor gear. If immediate washing is not possible, try to seal them up in a container or a plastic bag so that they will not contaminate anything else that they might have otherwise touched. It is possible for dry cleaning to eliminate the irritant, but it is important to let the dry cleaner know ahead of time that the clothing has likely come into contact with a toxic plant so that they can take the precautions necessary to handle it.
Vitamins

Menatetrenone

Menatetrenone (also known as Vitamin K2)

The foods we eat contains various nutrients, which are required for the overall growth and maintenance of our body. They regulate various functions of the body and keep it healthy and going. Omitting or skipping any one of the five nutrients could cause imbalances in the body and leave you malnourished. The five nutrients-Carbohydrates, fats, proteins, minerals and vitamins perform various roles in the human body.

Carbohydrates serve as the major source of energy for the body. Food items that consist of Carbon (C), Hydrogen (H) and Oxygen (O) constitute carbohydrates. This nutrient generates glucose in the body and adds energy in calories. Too much Carbohydrates can lead to obesity whereas too little can create fatigue and tiredness. Proteins are responsible for cell and tissue growth. Foods from animal sources such as milk, eggs, cheese, etc. contains proteins in great amount. Food materials consisting of oxygen, hydrogen, carbon and nitrogen form proteins.
Vitamin K Benefits
Fat is also an essential element for growth. However, too much fat can lead to blockages, high cholesterol levels, variations in blood pressure and other cardiovascular diseases. The role of Minerals is different from other nutrients. They are responsible for the psychological changes and actions. They influence the working of the nervous and the skeletal system to a great extent. Now comes the most essential constituent of all the five nutrients-Vitamins. One should keep a balanced vitamin intake for normal growth of the body and brain. Out of 13 vitamins, Vitamin A, D, E and K are called fat-soluble vitamins whereas the other nine B and C vitamins are water-soluble.

Vitamin K

Since long ago Vitamin K has been associated with blood clotting. The family of Vitamin K includes members such as phylloquinone (Vitamin K1), Menaquinones (Vitamin K2) and Menadionione (Vitamin K3). All these vitamins are accountable for the healthy functioning of the bones, the heart and the liver. Vitamin K1 is found in green leafy vegetables like Lettuce, Spinach, Cabbage, Broccoli and vegetable oil. Vitamin K2 is found in fermented food and processed items. Vitamin K3 is found in the items, which we include in our regular meals.

Functions of Vitamin K

Vitamin K plays various roles in maintaining the body. These nutrients convert the glutamate deposits of proteins into the gamma-carboxyglutamate group using the enzymatic process of carboxylation. Vitamin D and C along with magnesium and Zinc help in structuring the bones. Vitamin K maintains the plasma level, which in turn supports the functions of the bone. The intake of vitamin K really benefits the vascular system. It prevents the loss of elasticity of the tissues and flushes the calcium deposits within them.

Vitamin K not only acts as an anti coagulator but also helps in blood thinning and clot removal. Due to this quality, it is always advisable to consult a doctor before consuming any medicine that contains Vitamin K2. Although Vitamin K is a lifesaver in many cases, it might prove to be catastrophic if taken in large amounts or overdoses. It has been known to attack the liver causing liver cancer.

Menatetrenone or Vitamin K2

Most of us have heard about Vitamin K but very few of us know what Vitamin K2 is. Vitamin K2, which is also called Menatetrenone, plays an important role in blood clotting and tissue building. It has antineoplastic effects on the cancer cell line that contains hepatocellular carcinoma cells. It is effective in bone growth and development. It is seen that very little Vitamin K2 is present in the regular food we eat. Therefore, for those who require extra doses supplements are the solutions.

Vitamin K2 consists of Menaquinones, which are Vitamin K compounds. These compounds have unsaturated chains, which are usually detected in animals and bacteria. Menatetrenone is generally produced by certain bacteria, which is found in egg yolks, cheese, Natto-a soy product, butter and cow liver. Though the dietary value of K2 is less than that of Vitamin K1, its deficiency causes prolonged effects on the body.

Importance of Menatetrenone

Vitamin K2 or menatetrenone enables carboxylation of a constituent in a protein called Glutamate. During this process, the protein combines with calcium and helps in blood clotting. Due to the presence of carboxyglutamates calcium is transported from one place to another within the body easily. When compared to Vitamin K1, Menatetrenone is more effective in the osteoclastogenesis process and hypocholesterolemic effects. This vitamin can also slow atherosclerotic progression.

Until 1974, Vitamin K remained undiscovered. Studies have been done on this aspect for the last thirty years. Menatetrenone is otherwise an alternative form of Vitamin K1. It not only boosts bone health but also keeps any blood disorders at bay. K2 prevents osteoporosis and maintains the bone density in brittle structures. The nutrient that is derived out of Vitamin K2 stimulates apoptosis in Leukamia cells and increases the upshot of retinoic acid.

Vitamin K2 acts as an anti-inflammatory medication. IL- 6 is a substance, which keeps inflammatory actions in the body under control. The level of this constituent is high in those suffering from arthritis, Alzheimer’s disease and atherosclerosis. High levels of IL-6 also create disabilities related to mobility.
The pancreas contains the second highest deposits of vitamin K. This organ regulates and controls the production of sugar and insulin. As per a few studies, a deficiency of Vitamin K leads to Type II diabetes in many cases. Vitamin K is a rich antioxidant that shields the liver from calcium deposits. Extensive calcium deposits and scratches in the blood vessels cause Alzheimer’s disease. This can be prevented by proper doses of vitamin K.

Role of Menatetrenone/ K2 in Bone development

Menatetrenone (vitamin K2) reduces the risk of fractures and bone related diseases in women who experience menopause. Osteoporosis is a bone related disease in which the bones start loosing their efficiency and become brittle. Any minor blow can cause fractures in such cases. Menopause is a stage where women stop having their menses. Very few are lucky enough to experience a menopause without side effects. Most women face one or more problems during this phase. Fractures are usually caused due to variations in the bone mineral density. Various treatments are available for this condition where Menatetrenone is given along with Bisphosphonates for effective results. K2 works on the bone construction and strength during the osteoporosis treatment.
While Vitamin K2 is called Menatetrenone, Phylloquinone is the common name for Vitamin K1. Studies that involved the functions of both the vitamins tell of the great differences in their roles. They perform various tasks on the metabolism of bones.

Functions of Menatetrenone (Vitamin K2) vs Phylloquinone (Vitamin K1)

  • Regular intake of Menatetrenone or Vitamin K2 in any form reduces the chances of bone fractures and damage.
  • Vitamin K2 reduces the formation of Osteoclasts, the cells responsible for destroying bone tissue. Although phylloquinone has more or less the same qualities of K2 it is much less preferred for clinical and pharmacological purposes. Phylloquinone cannot prevent the tearing of bone tissue and is useless in treating bone related problems.
  • K2 plays the main role of backing osteoblasts, the cells that are involved in the creation of new bone. Menatetrenone helps in increasing the cells and enhancing their functioning smoothly.
  • When compared, Menatetrenone augments Apoptosis- cell death of osteoclasts whereas phylloquinone remains inactive in this matter.

Dietary forms (Vitamin K1 and Vitamin K2)

An ideal daily diet includes all nutrients in a balanced manner. In that diet, about 80% of Vitamin K1 comes from vegetables, especially green vegetables. There is no specific source of Vitamin K2. It is acquired through the good bacteria found in our digestive tracks. A few fermented and yeast based food also consist of Vitamin K2. However, both K1 and K2 work for bile secretion in the liver. That is the reason why the liver is the first point of attack when the vitamin becomes deficient in the body.

History of Vitamin K

A Danish scientist named Henrik Dam experimented with the effects of cholesterol using chickens from his backyard. He kept a few of them on a cholesterol free diet and the others on a normal diet. After a few weeks, the ones on a cholesterol free diet started bleeding due to hemorrhage. When he tried to feed them food with cholesterol it did not work. He found that it was not only cholesterol that was missing from the food but another compound as well. This was a coagulation vitamin, which he later named K. It meant Koagulations vitamin. The coagulation was later reinstated when the chicks were fed Vitamin K rich food.

For many years, this chicken experiment was used as a model to calculate the vitamin K content in food. A jaundice patient with severe hemorrhage was treated with doses of vitamin K in 1938. This was the first success of Vitamin K in treatment of humans. Later various universities and research organizations took these experiments forward to present diverse utilities of Menatetrenone and other forms of vitamin K.

East vs West

Lets us use a few cases of people living in Eastern countries and western parts of the world in studying the consumption of Vitamin K2. The diet followed by the people of the US includes much less menatetrenone when compared to the diets of those in eastern countries. Even if they try to get the best possible sources of K2 by eating egg yolks, cheese, butter, cooked Broccoli and goose liver, they do not get more than 2.1 micrograms of K2. On the other hand, the diet of the average Japanese person includes grilled fish, rice, seaweed, Natto-a fermented soy substitute and pickle. Natto is considered the richest source of Menatetrenone.
Vitamin K Side Effects
This speaks a lot about the fittest lifestyle of the Japanese and the impact of Menatetrenone/ K2 in their regular lives. While items such as soy bean curd, soymilk, tofu and soy sauce are all derived from Soybeans they are not considered rich sources of Menatetrenone. It is just the Natto, which fights brittle bones and prevents fractures.

How does Menatetrenone effect the bone mineral Density?

Bone Mineral Density is the measurement of calcium and other minerals present in the bones. It determines the firmness and the strength of the bones. When you look at the cross section of a bone you will find a network of hard tissues running all over in a criss cross manner. The more the density is the denser is the network inside the bones. When there is a drop in the density the network becomes thinner and fragile. Such bones are prone to frequent fractures.

How Vitamin K deficiency occurs?

Vitamin K deficiency occurs due to various reasons. Leafy vegetables that are rich in Vitamin K are Brocolli, Collard greens and Lettuce. These are the ones, which most people do not eat enough abundantly. Medications such as painkillers, especially Aspirin, antibiotics and antithrombotic drugs lead to serious bleeding and blood clots. Asprin is a blood thinner, if taken too often it can obstruct Vitamin K and lead to health issues. Salicylates are another constituent, which are found in spices, nuts and mint.

This is also a blood thinner, which can lead to Vitamin K deficiency. Vitamin K is produced by the bacteria present in the intestines. Excessive intake of Aspirin and antibiotics can kill that bacteria causing a severe deficiency of Vitamin K. Usually doctors recommend that you have yogurt after a heavy dose of antibiotics. This induces probiotic elements, which contain acidophilus bacteria that encourage the production of Vitamin K and promote better digestive action. Supplements are available at major stores. They are stored in refrigerators to increase their life span.

Vitamin K and anticoagulants block each other’s function when taken without proper medical supervision. Too much intake of other vitamins can also block the benefits of Vitamin K. A common sign of an overdose or deficiency is nosebleeds.

Other factors that influence the deficiency of Vitamin K are yeast infections, excess consumption of antacids, alcoholism and any prolonged illness. A few chemicals that are used as preservatives can also disturb the functions of Vitamin K in the body.

Who is prone to a Vitamin K2 deficiency?

Not all of us are deficient of nutrients. There are some who are deficient of certain nutrients due to their lifestyle and eating habits. Those who suffer malnourishment for a long period or those suffering from cystic fibrosis, celiac disease, alcohol abuse, liver dysfunction or chronic intestinal resection are prone to Vitamin K2 deficiency. Under the advice of doctors, these people need to take regular doses of Vitamin K2 supplement for their body to function properly.

Birth defects due to deficiency of Vitamin K2

The symptoms of deficiency of Vitamin K includes nosebleeds, blood in the urine, eye hemorrhage, heavy bleeding during menstruation, fractures, bleeding gums, anemia, hemorrhaging, calcium deposits in the heart’s walls, delayed clotting, osteoporosis, hypercalciuria, hematomas, and gastrointestinal bleeding. A deficiency of Vitamin K2 in pregnant mothers will cause the yet to be born infant a few abnormalities and defects such as a flat nose, cupped ears, short fingers and an undersized nose and face.

If the deficiency occurs due to over dosage of convulsant drugs, the following defects are possible:

  • Microcephaly
  • Hypertelorism
  • Overlapping fingers
  • Neural tube defects
  • A short nose
  • Growth defects
  • Cardiac problems
  • Mental retardation
  • Epicanthal folds
  • Learning disabilities

A healthy person requires about 200 to 500 mcg of Vitamin K every day to remain healthy and fit. When supplements containing Vitamins K, D and minerals are consumed together, the best results can be achieved. Very few side effects have been reported after the consumption of vitamin K1 at 1 mg per day and the consumption of vitamin K2 at 45 mg per day in adults.

Menatetrenone Supplements

For those with any level of vitamin K deficiency there are supplements available which could cover up the requirements of the body. Butter oil is a rich source of Vitamin K. It not only works on the whole body but also creates exclusive impacts on the skin. Just apply some oil on your skin and leave it overnight. See the change and glow on your skin the next day. Vitamin K2 is present in the food we eat. Therefore, supplements are not generally required. However, if you feel you lack that nutrient you may take supplements, which are available in the market.

Medicines such as Coumadin and Warfarin are rivals of Vitamin K. If you are undergoing oral anticoagulant therapy, you should not take Vitamin K supplements. If the dose is 150mcg or less per day, a parallel intake of a Vitamin K2 supplement does not create any problems. However, consult your doctor before you take the supplements.

It is said that cows perform multi tasks in their stomach. They chew cud and in this process ferment Vitamin K2. When we eat K2 rich food it is converted into bile and this process leads to less Vitamin production. The bile in the gall bladder absorbs the fermented food, which keeps the LXR and FXR bound in the nucleus. These are responsible for the cholesterol and inflammatory actions in the body.

GCGA Proteins (Gamma Carboxyglutamic Acid)

The vitamin does not act on the cells of the body directly; it acts as a support in carboxylation process through an enzyme contained in Glutamic acid to create amino acid (Gamma Carboxyglutamic Acid) in plasma proteins. Plasma proteins control the calcium deposits in the tissues. GCGA proteins include OC (osteocalcin), an important constituent of human bones. Matrix GCGA is a protein that is manufactured in the cartilage and arteries.

The required amount of Vitamin K varies from person to person based on his age and health condition. Infants require about 5 micrograms of Vitamin K whereas an adult male requires 80 mcg. A grown up female requires around 65 mcg of Vitamin K.

The four main body parts that are influenced by menatetrenone are the liver, bones, arteries and cartilage. When vitamin K is deficient, the proteins are formed without GCGA, which hinders the normal functioning of these parts. Along with the other functions, the four main organs extract vitamin K from the blood and distribute it to other parts. Vitamin K as a whole is regarded as a life saving nutrient both in human beings and animals.

An adequate supply of Vitamin K to all four parts has to be maintained. The human liver takes the most Vitamin K so the cartilage, bones and arteries may be deprived of the nutrient and GCGA at times. If this happens, blood clotting, maintenance of the cardiovascular system and other functions will not take place as usual.
The recent discoveries and production of supplements of vitamins in various forms has benefited people in many ways. However, most of the FDA approved supplements are made for the liver.

Clinical Conclusions

Studies were conducted on a few postmenopausal women ages 50-60 who were treated with daily supplements continuously for 3 years. They were divided into 3 groups. The first group received only maltodextrin; the second group was given 150mg of Magnesium, 500 mg of calcium, 320 IU of vitamin D3 and 10 mg of zinc as daily supplements. The women in the third group received all the minerals and an extra dose of 1mg of Vitamin K and D3 per day. The results taken after 3 years showed that the groups who did not receive Vitamin K did not have the advantages of the ones who received a balanced amount of all nutrients including an extra dose of Vitamin K.

The latter group thrived with no bone problems or other health issues for a long period of 10 years.
Before taking any supplement consult your doctor and take the advised tests. Purchase the supplements only from an authorized dealer. Check if the product suits your health conditions and requirements. Pregnant women and lactating mothers have to take special precautions while taking any supplement. See the label and instructions provided on the packet. The FDA is the agency that approves the supplements in foods and artificial supplements. Supplements are available in the form of tablets, capsules and drops. What will suit you best will be decided by your doctor.

Health is wealth and it does not take too much to maintain good health. A balanced diet, regular care and proper medication are the secrets to a long and healthy life.

Vitamins

B Vitamins

The B Vitamins are a group of eight water-soluble vitamins that perform many important cell and body functions. Since these vitamins perform so many important functions they are essential for good health. This group of vitamins is also known as B-Complex. Because these vitamins are water-soluble they are not stored in the body. What this means is that B vitamins must be replenished each day.
Uses for Vitamin B
B-vitamins are widely available naturally from both plant and animal sources and are also added to many foods such as cereals. A regular healthy, balanced diet usually supplies the appropriate amount of B Vitamins to support proper body functioning. If this is not the case, supplements are also available. Supplements are offered both individually and in a B-Complex supplement which includes all eight B vitamins. The following is an overview each of these eight B-vitamins.

Vitamin B1

Also identified as: Thiamin

Benefits

Vitamin B1 improves circulation, supports blood formation, aids in carbohydrate metabolism, and is necessary to produce hydrochloric acid, which helps digest food. It also helps to maintain the normal red blood count, and promotes healthy skin. It protects against the damaging effect of lead poisoning, and prevents edema or fluid retention in connection with heart ailments. Supplemental thiamin can help protect against some of the metabolic imbalances caused by heavy alcohol consumption. It may help protect against Wernicke’s encephalopathy. This condition is a form of brain damage seen in some alcoholics.

Sources

The greatest food sources of vitamin B1 are yeast, brown rice, egg yolks, legumes, liver, nuts, peas, poultry, rice bran, dulse, kelp, spirulina, wheat germ and whole grains. Vitamin B1 is also found in fortified breads, cereals, pasta, lean meats, fish, dried beans, peas, and soybeans.

Deficiency Symptoms

Since vitamin B1 is required for the metabolism of carbohydrates, fats and proteins, a vast array of symptoms can develop due to deficiency. These symptoms can develop in multiple body systems including the gastrointestinal system, causing indigestion and constipation, and the central nervous system, causing reduced alertness, nerve irritation, pain, numbness and weakness. Cardiovascular symptoms can include weakening of the heart muscles, causing edema in the lower limbs and difficulty breathing. Deficiency in the U.S. is mainly seen in people who abuse alcohol because alcohol prevents the body from absorbing the vitamin properly.

Recommended Daily Allowance of Vitamin B1

Men – 1.5 mg., Women – 1.1 mg., Pregnant women – 1.5 mg., Children – 1.1 mg.

Vitamin B2

Also identified as: Riboflavin

Benefits

Vitamin B2 helps prevent and is used to treat migraine headaches, cataracts, rheumatoid arthritis, and a number of skin disorders such as acne, dermatitis, and eczema. In the treatment of anemia, adding Vitamin B2 to iron supplements has shown to increase its effectiveness. This vitamin is particularly helpful in counteracting the tendency towards glaucoma.

Sources

High levels of Vitamin B2 are found in the following foods: cheese, egg yolks, almonds, organ meats, whole grains, wild rice, soybeans, milk, spinach, mushrooms, almonds, and poultry. Vitamin B2 is usually added to cereals and flour products. Keep these foods stored away from light to protect vitamin content.

Symptoms of Deficiency

Vitamin B2 deficiency has a great effect on the metabolism of carbohydrates, fats, and protein. All three of these basic food elements require Vitamin B2 if they are to be properly used by the body. A deficiency of this vitamin results in symptoms such as burning and itching of the eyes. Blurring of vision may also occur. The lips also become dry, chapped and sore. The first signs and symptoms of deficiency are a sore throat and sores at the corners of the mouth. Worsening symptoms include a swollen tongue, seborrheic dermatitis, anemia and weakened nerve function.

Recommended Daily Allowance of Vitamin B2

Men – 1.7 mg., Women – 1.3 mg. , Pregnant women – 1.6 mg., Lactating women – 1.8 mg.

Vitamin B3

Also identified as: Niacin, Nicotinic Acid, Niacinamide

Benefits

Vitamin B3 is a component in many important metabolic functions of the body. In addition, it is also used as a drug in treatment of some disorders. Vitamin B3 helps to maintain a healthy skin. Niacin dilates the blood capillary system. This vitamin is also essential for synthesis of the sex hormones, namely, estrogen, progesterone, and testosterone, as well as cortisone, thyroxin, and insulin. It also maintains mental and emotional well-being.

Sources

Vitamin B3 is found in beef liver, brewer’s yeast, lean meats, poultry, fish, eggs, cheese, soybeans, nuts, whole grains, green vegetables, cooked dried beans, and milk.

Symptoms of Deficiency

Pellagra is a disease caused by a vitamin B3 deficiency. However, it is rare in the United States. Symptoms include loss of appetite, skin rash, diarrhea, mental changes, swollen tongue, and digestive and emotional disturbance.

Recommended Daily Allowance of Vitamin B3

Men – 19 mg., Women – 15 mg., Pregnant women – 17 mg., Lactating women – 20 mg.

Vitamin B5

Also identified as: Pantothenic acid, Pantothenic Acid

Benefits

Vitamin B5 plays an important role in emotional well being. This vitamin enhances the body’s production of cortisol, a hormone that helps control stress, anxiety and depression. Vitamin B5 is also important for maintaining healthy skin, nerves, glands and muscles, and helps to maintain the digestive tract and fight allergies.

Sources

Rich sources of Vitamin B5 include liver, kidney, yeast, egg yolk and broccoli. Other good sources include, chicken, fish, milk, legumes, mushrooms, sweet potatoes and whole grain cereals.

Symptoms of Deficiency

Naturally occurring Vitamin B5 acid deficiency in humans is vary rare. However when deficient diets were fed to volunteers the following symptoms were observed: loss of appetite, indigestion, abdominal pain, headache, fatigue, mental depression, sleeplessness, numbness and tingling of hands and feet.

Recommended Daily Allowance of Vitamin B5

4 to 7 mg. for adult men and women

Vitamin B6

Also identified as: Pyridoxide, Pyridoxine

Benefits

Vitamin B6 is beneficial if you suffer from water retention, and is necessary for the production of hydrochloric acid and the absorption of fats and protein. Vitamin B6 also aids in maintaining sodium and potassium balance, which is vitally important for normal body functions. Vitamin B6 also promotes red blood cell formation. In addition, this vitamin is required for the production of hydrochloric acid and magnesium. Vitamin B6 is also known to be helpful in the treatment of allergies, arthritis, and asthma.

Sources

Good dietary sources of vitamin B6 include chicken, turkey, tuna, salmon, shrimp, beef liver, lentils, soybeans, nuts, avocados, bananas, carrots, brown rice, bran, sunflower seeds, wheat germ, and whole-grain flour.

Symptoms of Deficiency

Irritability, nervousness and insomnia as well as overall weakness, skin conditions such as dermatitis and acne as well asthma and allergies might develop when vitamin B6 is deficient. Symptoms may include nails that are ridged, an irritated tongue as well as changes to your bones – which can include osteoporosis and arthritis. Kidney stones may also appear. A deficiency of Vitamin B6 may also eventually lead to loss of muscular control, migraine headaches, diseases of old age, and premature senility.

Recommended Daily Allowance of Vitamin B6

  • Infants:0 – 6 months: 0.1 milligrams per day (mg/day), 7 – 12 months: 0.3 mg/day
  • Children: 1 – 3 years: 0.5 mg/day, 4 – 8 years: 0.6 mg/day , 9 – 13 years: 1.0 mg/day
  • Adolescents and Adults: Males age 14 to 50 years: 1.3 mg/day, Males over 50 years: 1.7 mg/day , Females age 14 to 18 years: 1.2 mg/day , Females age 19 to 50 years: 1.3 mg/day , Females over 50 years: 1.5 mg/day

Vitamin B7

Also identified as: Biotin

Benefits

Vitamin B7 plays an essential role in the conversion of fatty acids and glucose into the fuel the body needs for energy. It also helps build and maintain muscle tissue, bone marrow and nervous system tissue. This vitamin is also thought to be beneficial to the health of skin, hair and nails.

Sources

Vitamin B7 is widely available in foods but few foods have a very high concentration. Milk, liver, egg yolk, legumes, nuts and a few vegetables are the most important sources of biotin. The natural availability of biotin varies greatly among foods.
Types of Vitamin B

Symptoms of Deficiency

Symptoms of deficiency include loss of appetite, nausea, hair loss, and scaly red rash around the eyes, nose, mouth and genital area. Neurological symptoms include depression, lethargy, hallucination and numbness and tingling sensation in the hands and feet. Since biotin is prevalent in foods, natural Vitamin B7 deficiency is rare.

Recommended Daily Allowance of Vitamin B7

Men – 200 mcg. ,Women – 150 mcg. ,Children – 100 mcg.

Vitamin B9

Also identified as: Folic Acid, Folate, Folacin and Pteroylglutamic acid

Benefits

Vitamin B9 helps the body produce and maintain new cells. It also offers protection against certain types of cancers and is important in protection against heart disease. Folic acid is the single most important nutrient for a pregnant woman and her developing fetus. Eating a diet rich in vitamin B9 will help to ensure healthful pregnancy for woman and the delivery of a healthy baby. Folic acid also improves lactation.

Sources

Natural sources of folic acid include fresh leafy green vegetables, such as spinach and turnip greens. It is also found in whole grains, starchy vegetables, dried beans and fruit.

Symptoms of Deficiency

A sore, red tongue is one sign of folic acid deficiency. Other potential signs include anemia, apathy, digestive disturbances, fatigue, graying hair, growth impairment, insomnia, difficult breathing, memory problems, paranoia, weakness, and birth defects in one’s offspring.

Recommended Daily Allowance of Vitamin B9

Men – 200 mcg. ,Women – 180 mcg. ,Women of childbearing age – 400 mcg.

Vitamin B12

Also identified as: Cobalamin, Cyanocobalamin

Benefits

Vitamin B12 plays an important role in the production of energy from fats and proteins. Vitamin B12 is also critical to the central nervous system. It maintains the sheath that surrounds and protects nerve fibers and promotes their normal growth. Since vitamin B12 shares a close metabolic interrelationship with folic acid, it is indirectly involved in the formation of red blood cells. Other functions and benefits include its role as an oxygen carrier, metabolizing fat, improving neurological disorders, and enhancing the immune system.

Sources

The richest sources of vitamin B12 are liver, kidney, milk, eggs, fish, cheese, meats and poultry. Vitamin B 12 is not found in many vegetables; it is available only from sea vegetables, such as dulse, and kelp. It is also available in and soybeans and soy products. In addition it is present in the herbs alfalfa, bladderwrack, and hops.

Symptoms of Deficiency

A deficiency of vitamin B 12 may cause a condition called pernicious anemia. It may lead to a poor appetite and retardation of growth in children, chronic fatigue, a sore mouth, a feeling of numbness or stiffness, loss of mental energy, and difficulty in concentration. Deficiency of vitamin B12 also results in neurological symptoms such as numbness and tingling of the arms and legs, difficulty in walking, amnesia, depression, disorientation and dementia, with or without mood swings.

Recommended Daily Allowance of Vitamin B12

  • Infants:0 – 6 months: 0.4 micrograms per day (mcg/day),7 – 12 months: 0.5 mcg/day
  • Children: 1 – 3 years: 0.9 mcg/day, 4 – 8 years: 1.2 mcg/day , 9 – 13 years: 1.8 mcg/day
  • Adolescents and Adults: Males and females age 14 and older: 2.4 mcg/day

References:

www.nlm.nih.gov/medlineplus
www.Ods.od.nih.gov

Vitamins

Tretinoin

Tretinoin is the acidic form of vitamin A. It is also known as ATRA or all-trans retinoic acid. It is most commonly used to treat acne and other inflammatory skin conditions. It most commonly comes in gel or cream form and is sold under name brands such as Retin-A, Airol, Aberela, Renova, and Stieva-A.

It is also sold by Roche under the brand Vesanoid and is used to treat acute promyelocytic leukemia. It is also available as a generic through many pharmacies.

Dermatological Uses

The most popular use for tretinoin is as an acne treatment. It is also used as a treatment for photoaging, wrinkles, scars and other skin conditions. Some forms are available as a hair loss treatment. Tretinoin is also known to increase collagen production in the dermis, which minimizes the significance of stretch marks. It treats acne, dark spots and wrinkles by lightening skin, shedding old skin cells and regenerating new skin that is healthy, clear and smooth with tight pores that have regulated oil production.
Tretinoin Benefits
For most dermatological uses, tretinoin is distributed as a prescription gel or cream. Common dosages are .025% or .050%. Due to the fact that tretinoin makes skin extremely sensitive and thin during the first several weeks of use, dermatologists will typically prescribe the lowest possible dosage to patients and gradually increase it as needed.

The first several weeks of using a tretinoin cream are often unpleasant and will make skin look worse than it did in the first place, but the key is to continue use even through the unpleasant side effects in order to effectively treat skin and see significant, worthwhile results. Patients may also start off using tretinoin every other day or even every third day until skin adjusts and can gradually handle larger amounts of the prescription.

Cream and Gel

It is also important for patients to use as thin a layer of tretinoin cream or gel as possible. A little of this product goes a long way, and using a small amount allows the solution to quickly absorb into skin rather than sit on top of it.

Patients using tretinoin should also follow a strict and consistent cleaning regimen for their skin. For cleansing, an unscented, mild facial wash is ideal. Using a face brush or wash cloth will also help slough away dead or flaking skin that may result from using the product. Patients should also use a light moisturizer during the day with SPF 15 or higher in it. A night time moisturizer may also be applied over top of the tretinoin to prevent dryness or irritation. Tretinoin is typically only applied once a day before bed, as light and ultra violet radiation tend to deactivate the active ingredients in the product, causing it to be ineffective and increase the chance of a severe sunburn.

Acne Treatment

Studies have shown that young adults who used tretinoin as an acne treatment had less wrinkles or age spots later in life due to the regeneration of new, healthier skin and regulated oil production. Tretinoin is a popular solution to anti aging as it has shown to significantly slow the aging process.

Some patients experience severe side effects that cause more than the average irritation that typically occurs. If this is the case, tretinoin may not be the right product and other alternatives will most likely be considered. Many acne patients will go through several products before determining what is best for their skin type.

Accutane

Accutane is an oral acne treatment that is an extremely high dose of vitamin A, similar to tretinoin. Accutane is taken for severe nodular acne and is a last resort treatment if several other alternatives have been attempted with no success. It is typically taken for 6 months and will never have to be taken again after this time period. The first several weeks or months of taking the drug are often unpleasant for patients as it causes extremely dry skin, eyes and mouth, but the temporary side effects of the drug are considered to be worth the sacrifice in order to clear up acne that causes a lowered quality of life.

Accutane is a controversial drug as it poses severe side effects including depression, inflammable bowel syndrome, or even suicidal thoughts. It also causes a risk of serious birth defects, and women taking the drug must sign paperwork stating they will use at least two forms of birth control while taking the drug.

Accutane patients must also become part of the iPLEDGE program, which educates patients on all potential side effects, holds them to a contract stating they will not become pregnant or cause pregnancy while on the drug, and gives them a patient identification card so they can access the drug from a primary pharmacist.

Harmful Combinations

Accutane patients must not take any other vitamin A supplements while taking the drug. Several lawsuits have come about as a result of long-term illnesses or conditions caused by taking Accutane. Due to the education provided to patients regarding the risk involved with taking the drug, court cases regarding health issues caused by Accutane rarely end with the patient receiving any financial or medical benefit. The drug is highly effective in permanently clearing up acne and patients who follow guidelines and continue to take care of themselves rarely have any negative side effects.

Leukemia Treatment

Tretinoin is also used to treat acute promyelocytic leukemia, a cancer affecting the blood and bone marrow. This is the only form of cancer it is used to treat. It is usually mixed with a variety of other drugs to help grow blood cells that are functioning properly, thus overpowering the weak blood cells that cause leukemia. The typical dosage for a leukemia patient is 8-10 10mg capsules a day for 15 days. This is done about every 3 months until the cancer is cleared. The exact scientific conclusion regarding how tretinoin works and how it causes cells to mature and multiply is still unknown.

Patients who are taking tretinoin as a form of leukemia cancer treatment should notify their doctor if they have high cholesterol or have taken a tretinoin or high vitamin A product in the past. Those who have had negative effects as a result of vitamin A should also avoid taking it for this reason.

One of the most important factors for leukemia patients taking tretinoin as a treatment is that they avoid taking any sort of vitamin A during the process. Excessive amounts of vitamin A are dangerous and toxic. Even after the use of tretinoin as a cancer treatment, patients may be advised to avoid taking any vitamin A supplements for a long period of time. Large amounts of vitamin A will potentially stay in the system long after treatment has been completed.

Side Effects

Those who use tretinoin to treat skin conditions often experience scaling, itching, burning, redness or other irritation. Because of this, most dermatologists prescribe the lowest possible dosage of tretinoin to a patient and gradually increase the dosage as their skin adapts to the excessive amounts of vitamin A. It is also integral for patients using tretinoin on their skin to avoid direct sunlight, as it significantly increases the risk of extreme sunburn.
Tretinoin Side Effects
It is also important for dermatology patients to avoid hair removal procedures such as waxing or laser treatments while using any tretinoin product. The top layer of skin will become very sensitive and most likely come off right with the hair due to thinning and extra sensitivity. If patients using tretinoin use some sort of regular hair removal technique, it is important that they consult their dermatologist or aesthetician to determine whether or not they should discontinue the hair removal process while using the drug.

Additional Side Effects

Leukemia patients will also experience side effects while taking large amounts of tretinoin. Retinoic acid syndrome is often developed by patients taking the drug, and can be potentially life threatening if a follow up treatment is not given immediately. The syndrome leads to fever, weight gain, peripheral edema or dyspnea. Retinoic acid syndrome is also known to cause capillary leak syndrome, a rare condition where the size and quantity of pores within the capillaries are enlarged, causing leakage from the blood into interstitial fluid. This may cause dangerously low blood pressure and even organ failure. Side effects of this condition include nausea, abdominal pain, hypotension or even cardiopulmonary collapse.

Tretinoin is a teratogen, which is a category of drugs that cause birth defects, particularly skull abnormalities in fetuses and infants. Pregnant or nursing women are not advised to use any type of tretinoin during their pregnancy, nursing period or time when they are trying to get pregnant. Topical tretinoin, particularly gels and creams, are the safest form to use during pregnancy or nursing, as birth defects caused as a result of use are extremely low and almost nonexistent.

Many side effects caused by tretinoin or vitamin A treatments do not appear in patients for several months, or even years after the treatment has been completed. Due to the fact that some side effects show up so late, it is sometimes unknown as to whether or not they were caused by the tretinoin treatment or for an entirely different reason. Long term effects are typically caused by oral tretinoin treatments rather than topical treatments used for skin conditions.

Research Developments

In 2002, the European Respiratory Journal published information about a study suggesting that tretinoin reduced emphysema in lab mice by regenerating lung tissue and increasing elasticity in tissue and skin. However, a follow up study was done in 2006 which found inconclusive results that showed no significant or clinical benefit in mice infected with emphysema. It is still out that additional research must be done in order to consider tretinoin or other vitamin A treatments as a treatment for emphysema.

Sources:

http://en.wikipedia.org/wiki/Tretinoin
http://www.mayoclinic.com/health/drug-information/dr601381
http://www.drugs.com/accutane.html
http://www.cancer.org/docroot/CDG/content/CDG_tretinoin.asp

Herbs

Valerian Root

Valerian, also known as Valerian root, garden valerian, tobacco root, garden helotripe, all-heal, and setewale capon’s tale, is a perennial herb that can reach a height of over 4 feet and blooms every summer. The flowers of the valerian plant have a very potent smell, often described as smelling like aged cheese, spoiled milk, or old socks. The valerian plant is native to Europe, southern Africa, and northern Asia. Though not native to North America, valerian is grown and harvested for its many healthy benefits.
Valerian has a massive root system, a short rhizome (or underground stems), which contains valerian’s medicinal properties, bears pinnate leaves, and produces pink flower heads. Most valerian plants prefer rich, heavy loam with adequate moisture. In recent times, however, valerian has become a commercially farmed product and no longer requires a damp, rich environment in order to grow. The root and rhizome of valerian is ground and used for treating a wide variety of medical conditions, including insomnia, depression, pain, and stress-related digestive disorders. Valerian Root Health Benefits

History of Valerian

Valerian derives its name from the Latin word “valere” meaning to make strong; the Roman emperor Valerianus and several saints take their name from this Latin derivative. An additional translation of valerian is “to be in good health.” Used since the time of the ancient Egyptians, valerian was so revered for its medicinal benefits that it was referred to as the all-heal. Tenth century Arab apothecaries in Spain, Africa, and the Middle East combined valerian root with many other herbs and plants to cure pain, induce sleep, and as a general cure.

The use of valerian became widely popularized during medieval times. During World War I and II, valerian root was used in many European hospitals and medical units in treating stress caused by air raids. Valerian root continues to be popular in Chinese medicine. Used for over 2,000 years, valerian has been vital to Chinese medicine because of its pain relieving and calming abilities. Today valerian is a common supplement used to treat a myriad of ailments. It is easily found in groceries, pharmacies, and health food stores.

Legends and Literary References

It is rumored that valerian is spikenard, which is referred to in the Bible. Spikenard was referenced in the parable of when Christ’s feet were washed by Mary Magdalene.

Valerian also appears in many Hindu legends. The most common is the story of a newly married man planting valerian outside of his home for his bride as a symbol of his safe return. Years passed and the valerian flourished. Finally, the man returned home and his bride welcomed him warmly, knowing he was safe because the valerian had remained alive and beautiful.

Chaucer describes valerian as setewale in the Canterbury Tales. Setewale is used as a seasoning to a broth the cook prepares.

Many people believe that valerian will act as a repellant for unfriendly dogs. Centuries ago, gypsies would prepare and sell mixtures containing valerian to protect against unfriendly animals.

It is said that in the second century, Greek physician Galen would give people dried valerian root as a cure for insomnia and restlessness.

Uses

Best known for its tranquilizer and calmative effects, valerian is a popular sleep aid and treatment for anxiety and depression. Valerian has also been used in connection with menstrual cramps, muscle spasms, headaches, stress, nervous restlessness, and stress-related digestive disorders. Valerian has even been used as a natural treatment for ADHD in children and adults.

With no addictive properties, valerian is a safe alternative to calming drugs such as Valium. Scientific studies have shown that valerian works to promote relaxation by working with the nervous system to calm the brain and relax tensed muscles. This allows for sleep, reduced stress, muscle pains and cramps, and calms the body.

Valerian is effective in relaxing the muscles of the digestive tract, relieving many of the symptoms of stress-related digestive disorders like irritable bowel syndrome.

Working to relax the body, valerian has been shown to relieve pain. It is especially effective in the treatment of migraines, arthritis, and muscle pain. Nervous conditions such as epilepsy, multiple sclerosis, sciatica, and peripheral have all shown positive responses to valerian use.

ADHD Treatment

As a treatment for ADHD in children and adults, valerian has shown some benefits. It works together with the brain to slow down triggers that can cause hyperactivity and help the individual concentrate.

Valerian works to slow the heart, helping to regulate arrhythmias, treat those with tachycardia, and regulate blood pressure. It has also been found to have properties that help prevent blood clotting.

Valerian Supplements

Valerian supplements are very easy to find and rather inexpensive. Most commonly, valerian is found in pill or capsule form but at health food stores it can also be found in teas and liquid droppers.

Pills and capsules

Dried valerian root and rhizomes are used in creating valerian supplement pills and capsules. Valerian pills and capsules are packaged in 60 to 100 count bottles and are 400 to 530 mg. Pills and capsules are the most common and least expensive valerian supplement. They can be purchases at retail stores such as Target and Walgreens for approximately $7.99 for a 100 count 530 mg bottle. Valerian pills and capsules can be purchases online at websites such as amazon.com; a 3 pack of 100 count 400 mg bottle of valerian pills sells for $18.00.
Valerian Root Uses

Valerian tea

Valerian herbal teas have been used throughout history as a cure for many ailments. These teas contain dried root as well as other herbs such as chamomile or lavender. Unlike valerian pills, teas works almost immediately. Valerian tea should not be made with boiling water, as the temperature of the water may take away some of the medicinal properties of the tea. Use only hot water. Valerian teas are sold at many different health food stores, such as Whole Foods and Trader Joes, and range in price depending on the brand. At most health food stores, Yogi brand bedtime valerian tea sells for $4.99 for a box of 16 tea bags. Websites such as mothernature.com offer a wide variety of valerian teas at fair prices.

Valerian herb droppers

This liquid form of valerian can easily be added to food, water, or simply placed on the tongue. Often, veterinarians will prescribe valerian herb droppers for dogs and cats with anxiety. Add a few drops to the pet’s water dish and the valerian will work with the pet’s body to calm and soothe any anxiety. Valerian herb droppers are less common than pills or teas, but can be found in health food stores such as Whole Foods for approximately $9.99 for a 1 ounce bottle. A .25 ounce bottle of valerian can be purchases at www.lifesvigor.com for $5.38.

Dosage and Administration

Always check when taking Valerian supplements that the product contains 0.8 valerenic or valeric acid. There is no scientific evidence indicating a maximum dosage of valerian. For those who suffer from insomnia, valerian supplements range in dosage from 300 to 900 mg. Always try a smaller dosage and then move to a higher dosage if you do not see results.

When taking valerian pills for insomnia be sure to take the pill 30 to 45 minutes before going to sleep. Continue taking valerian pills 4 to 6 weeks after your sleeping state has improved to insure continued progress. When taking valerian teas, keep in mind that they are packaged differently by various manufacturers, causing some teas to be more potent than others.

Try several kinds of tea to find the one that works best with your body. You can even purchase dried valerian root from local health food stores and make your own mixture to treat headaches and menstrual pain. You can use 2 to 3 grams of dried valerian root in tea, up to several times daily. When using valerian herb droppers 1/4 tsp (1 to 2 mL) at a time. Valerian supplements can be taken with or without food. Do not take with caffeine and be sure to drink a full glass of water if taking a valerian pill or capsule.

Side Effects

For most individuals, valerian is a very safe supplement with no side effects. Fresh valerian root typically has no smell but dried valerian root can have a very potent and unpleasant aroma. There have been no documented cases of any drug interaction with valerian supplements. For some individuals, valerian can cause sudden nervousness, racing heart rate, and restlessness. There is some evidence that some cases of prolonged use of valerian resulted in withdrawal symptoms.

As it is a calmative, people who take valerian should not drive, operate heavy machinery, or engage in activity, which requires alertness.

Women who are pregnant or nursing should not take valerian, as the scientific community has not adequately studied its effects on infants and the fetus. Young children should also refrain from taking valerian supplements, as there have not been many studies on its effects.

Benefits

Valerian root has very few side effects and is proven to help treat insomnia, anxiety, and to calm the body. Because valerian is inexpensive and so accessible, many people can use it as a first line of treatment for their conditions. It does not leave you with a cloudy, foggy feeling when used as a sleep aid and does not contain the potentially harmful side effects of prescription medications.

Herbs

Chamomile

Chamomile, known as a popular variety of tea, is actually made up of several different daisy-like plants that belong to the Matricaria genus. The genus Matricaria come from the Latin word matrix which means “womb.” Chamomile plants and can be different species; for example, Roman chamomile, or Chamaemelum nobile, is a different species than German chamomile, or Matricaria recutita. Chamomile is most commonly used as a tea and acts as a sleep aid.

History of Chamomile

Ancient Egyptians admired chamomile for its healing powers and even offered it to the sun god Ra because it was considered so valuable. In ancient Rome, chamomile was used added to drinks for flavor and burned as incense. In Greece, physicians would give chamomile to people with fevers and women with female disorders. German chamomile has been taken as a digestive aid dating as far back as the first century CE. Chamomile was considered so useful by British doctors that they included it in their medical bags both in Great Britain and in the American colonies. Today, chamomile revered for its many medicinal uses.
Chamomile Herbal Remedies

Myths and Legends

Many cultures thought that chamomile soothed the spirit and would make an unruly spirit gentle and kind. Chamomile was believed to attract love and prosperity and was a common ingredient in potions and concoctions. During the middle ages, chamomile was used as an ingredient in love potions. Gamblers would rub their hands with chamomile as a way to entice money into their pocket. Many cultures believe that if sprinkled around the property, chamomile will rid the home of any evil spirits or curses. It is rumored that Vikings rubbed chamomile on their hair to lighten it and give their hair a blonder appearance.

Description of Chamomile

German chamomile is typically found growing wild in Europe and northwest Asia. In parts of Europe and North America, German chamomile is farm raised so that it can be cultivated and sold for medicinal use. German chamomile is planted in the autumn and harvested in the summer. It is a sweet smelling plant, produces white, daisy-like flowers, and can grow to be over 2 feet tall. German chamomile is the most common variety of chamomile that is used as a sleep aid, burn treatments, and for other medicinal purposes.

Native to western Europe and northern Africa, Roman chamomile has become commercially farmed worldwide in temperate regions. The primary exporters of Roman chamomile are Great Britain, Belgium, France, and Italy. Roman chamomile is an aromatic perennial that produces feathery leaves, white, daisy-like flower with yellow centers, and grows to be approximately 20 inches tall. Just like German chamomile, Roman chamomile flowers are harvested during the summer.

Uses of Chamomile

Chamomile is commonly known for its ability to act as a sleep aid. Calming to both adults and children, chamomile does not interfere with activities such as driving or other tasks that require concentration and alertness. It is safe to give to children of any age. Chamomile is ideal for relaxing and calming oneself after a stressful day.

Chamomile is also used to soothe ulcers or other stomach problems that are aggravated by anxiety. Muscle pain, twitching, and muscle spasms that are a result of stress can all be reduced by chamomile because of its ability to relax and calm the body.

Menstrual cramps and sleep disorders related to premenstrual syndrome (PMS) also show improvement with the use of chamomile. Chamomile has been found to contain strong anti-inflammatory and antispasmodic properties that are particularly effective in treating stomach and intestinal cramps. When chamomile is harvested during the early stages of flowering, it can help to relieve gas, bloating, and irritable bowel syndrome. Chamomile also is able to reduce the pain and cramping sensations associated with these stomach ailments.

Clinical Evidence

A German study found that chamomile contains valuable antimicrobial agents. Chamomile is able to rid the body of bacterial toxins and small quantities of chamomile oil have been shown to inhibit staphylococcal and streptococcal strains of bacteria. Drinking chamomile tea combined with other antimicrobial herbs, such as thyme, Echinacea, or goldenseal, reduces the severity of internal infections. Chamomile can also be used topically to treat infections, burns, and inflammation.

Internal Uses

Chamomile tea is so popular among people that it is found in every grocery store aisle. Chamomile tea is used as a mild sedative, helps to relieve insomnia, eases the pain of teething for young children, and relieves many stomach pains. Additionally, drinking chamomile tea regularly has been shown to reduce pain associated with arthritis and other painful inflammations. Large doses of chamomile tea can reduce the severity of symptoms associated with colds and flu such as fever, sore throats, and chills.

External Uses

Chamomile is often infused with other natural ingredients in shampoos and conditioners. Hair products containing chamomile leave hair feelings moisturized, not heavy, and very manageable. Dried chamomile is found in potpourri, herb therapy, and aromatherapy. The dried chamomile found in these helps to relax and calm the body and relieves it from stress. Chamomile can be applied to the skin to relieve sunburns, aching muscles, and mild burns. Often, chamomile is found in cosmetics as an anti-allergenic agent. Unused chamomile tea is can be given to plants as a liquid feed and plant tonic. Chamomile has been shown to be quite effective against a number of plant diseases. Many perfumes are made from an essential oil derived from chamomile. Dried chamomile flowers can even act as an insect repellant.
Chamomile Uses

Dosage

There is no universal dosage method for chamomile. Studies have shown that consuming ½ to 3 drops of chamomile essential oils to be beneficial as a sleep aid and to help ease stomachaches and cramps. Teas can be consumed safely one to four times a day. When using chamomile ointments, it is recommended that they contain 3% to 10% chamomile for best results.

Side effects

Chamomile is considered one of the safest herbs and has little side effects. A potential side effect associated with drinking chamomile tea is drowsiness. Because chamomile tea can be used as a sleep aid, drowsiness is always a possibility. Those who are allergic to ragweed pollen or have hay fever may have an allergic reaction to chamomile. Moderation is key with chamomile to avoid any adverse reactions. In some individuals, high doses of chamomile may cause vomiting and skin irritations. Do not use chamomile if pregnant. Chamomile was once used as a mixture of herbs to induce abortions during the middle ages. Those who are on blood thinners also avoid taking chamomile. Studies have suggested that chamomile has an ability to thin the blood by containing properties such as coumarin, which act as blood thinners.

Home Remedies

Stomach Cramps

Prepare a cup of lightly sweetened chamomile tea. Drink the tea twice a day, once in the morning and once in the evening, until symptoms are gone.

Insomnia

30 to 45 minutes before bedtime, make a strong cup of chamomile tea. Drink the tea and get ready for bed as usual.

Chamomile bath

A chamomile bath can relieve many ailments such as colds, stress, PMS, and itchy skin. There are several ways to prepare a soothing chamomile bath. Place ½ to 1 cup fresh or dried chamomile tied in linen bag and place it in the hot tub water. Let the bag soak for at least 10 minutes. Remember, do not add soap to bath. Another way to create a relaxing chamomile bath is to combine 10 to 20 drops of chamomile essential oil in with bath salts to the bath water.

Burns and Scrapes

Rub a small amount of chamomile essential oil gently across the burned or scraped area once a day. Another treatment for burns and scrapes is made by brewing 3 chamomile tea bags to one cup of water. Once the water has cooled, dip a clean cloth into the tea and use it as a compress on the affected areas.

Dark Circles

A simple remedy for reducing the appearance of dark circles is to dip 2 chamomile tea bags in warm water. After 5 minutes, remove the tea bags from the water and allow to cool until room temperature. Once cooled, place the teabags on the eyes at night as a compress.

Where to Purchase Chamomile

Chamomile teas are available in the tea aisle at most grocery stores. One of the most popular selling brands of chamomile tea is Celestial Seasonings. Celestial Seasonings can be found at Walmart, Target, Walgreens, as well as many health food stores for approximately $4 for a box of 20 tea bags or online at drugstore.com. Chamomile can be also be purchased in the forms of dried flower heads, liquid extract, essential oil, or in creams and ointments.

Many health food stores carry dried chamomile as well as online websites such as www.herbspro.com. Dried chamomile typically sells for $9 a pound at health food stores or online at www.americanspice.com. Liquid extracts and chamomile essential oils are found at health food chains such as Whole Foods. These products tend to me more expensive. Essential oils sell for approximately $15 for a .5 ounce vial and liquid extracts sell for $11 at The Vitamin Shoppe or online at amazon.com.

Antioxidants

Melatonin

N-Acetylserotonin (NAS) is a precursor to melatonin which is hard to find over the counter. However melatonin is quite commonplace. It is used by many in tablet or capsule form as a sleeping aide and has been available as a dietary supplement in the United States since 1993. There is a lot more to this naturally occurring compound than its ability to bring on sleep. It is found in plants, microbes and animals. It circulates and regulates circadian rhythms of many biological functions in animals, and is activated by melatonin receptors.

Melatonin is  hormone synthesized and released from the pineal gland at night. It acts on specific high affinity G-protein coupled receptors to regulate a number of aspects of physiology and behavior, including circadian and seasonal responses, and some cardiovascular, retinal and immunological functions.
Melatonin Sleep Aid
As a hormone manufactured in the brain, melatonin plays a significant role in the natural sleep/wake cycle of the body. As night approaches, the concentrations of melatonin in the body increase up to 10 times more than during the day. This causes the feeling of sleepiness, which is why melatonin is often recommended as a sleep enhancer.

In plants, melatonin regulates the photo period in defense responses and works as a scavenger of reactive oxygen species. Many foods are known to contain trace amounts of melatonin, but not enough to elevate plasma melatonin levels. Those foods that contain traces of melatonin include ginger, tomatoes, oats, barley and bananas. Melatonin’s precursor is serotonin. Serotonin’s precursor is tryptophan, which is a chemical found in turkey, which is why after eating turkey many feel like napping.

There are two kinds of melatonin — natural and man-made or synthetic. The pineal gland of animals produces natural melatonin, which could be virus contaminated and not recommended. Synthetic melatonin is not likely to be contaminated, and is most often recommended.

History

Researchers have known about the pineal gland for literally thousands of years. Philosopher René Descartes referred to the pineal gland as the “seat of the soul,” believing that emotions originated from this interesting gland. Although the pineal gland has been studied for centuries, its function was not truly understood until the 20th century. During the 50s, Yale University researchers found that melatonin was connected to the pineal gland, and the link between hormonal influences and sleep, as well as a possible link to cancer became the focus of study.

During the 90s, melatonin was made available on the market as a dietary supplement. It is available without prescription in the United States, France and Canada. There are many countries that do not sell over the counter melatonin.

As stated, Melatonin is available without a prescription in the United States, but melatonin products are not yet approved by the U.S. Food and Drug Administration, and purity, safety and effectiveness is generally not guaranteed. As of June 2010, there will be FDA rules to make sure that all dietary supplements will comply with “good manufacturing practice” and will be made with controls that produce consistent products that are contamination free with proper labeling. Any adverse effects or events will be required by law to be reported to the FDA, and the FDA will enforce requirements.

Melatonin Uses

People use melatonin for a variety of reasons including:

Jet lag – When taken orally on the day of flight and continued for several days before a trip, the number of days to maintain a relatively normal sleep pattern is reduced, thereby diminishing the the length of time that is required to fall asleep. Melatonin studies show that those who take it prior to travel are more alert and less tired during the daytime hours.

Melatonin has also been found to benefit those with delayed sleep phase syndrome, allowing for a more normal sleep pattern and duration. More studies are being done to support this claim.

Older people who suffer from insomnia seem to benefit from taking melatonin before bed, decreasing the time it takes to fall into a restful night’s sleep. There are reports that the elderly have an improved quality of sleep and are more alert when they rise.

The use of melatonin for sleep enhancement is quite popular and used by healthy people to reduce the time it takes them to fall asleep. There have been many studies done to support the fact that melatonin does decrease the amount of time it takes a healthy individual to fall and stay asleep.

Melatonin may also help to regulate changes related to age affecting the rhythm of body temperature, as well as its beneficial role in delaying macular degeneration of the eyes in older individuals. It is also being studied as an anti inflammatory treatment and as a treatment for anxiety prior to surgery.

As a treatment for cancer, human trial studies are ongoing in administering melatonin to patients with several types of malignancies including tumors of the liver, breast, lung, testicles, pancreas and brain. At this time, there is no clear evidence that melatonin decreases or increases the side effects of chemotherapy or the effectiveness of other cancer treatments combined with melatonin therapy.

Studies have also been done to see if melatonin can be used to treat migraine, cluster and tension headaches. There is some research that suggests melatonin may be beneficial, but more studies are needed to make a conclusive recommendation.

Melatonin Side Effects To Watch For

Some common side effects of melatonin include dizziness, irritability, fatigue, vivid dreams, nightmares, confusion and disorientation. These symptoms disappear when a person stops taking melatonin. There have also been some studies done that indicate melatonin might increase the risk of seizures, especially in children with neurological disorders. However, other studies have reported that melatonin actually reduces the likelihood of seizures when taken regularly. To this day, melatonin and seizures remains controversial, and anyone taking it for seizures should be closely monitored by a physician. Other reported side effects include dysphoria, paranoia, hallucinations and euphoria.

Patients who suffer from depression or other psychiatric disorders taking melatonin should be followed closely by a physician. If patients are taking blood pressure medication and melatonin, significant drops in blood pressure may occur, as well as increases in cholesterol levels. In rare cases, heart rhythm deviations have been related to melatonin intake. For those patients with type 1 diabetes, melatonin may reduce glucose tolerance and sensitivity to insulin. It is advised that these patients discuss melatonin usage with their physician.

In men taking melatonin, cases of gynecomastia have been reported and decreased sperm counts. Decreases and/or increases in luteinizing hormone levels, progesterone, thyroid hormone, prolactin, oxytocin, cortisol, growth hormones and vasopressin have also been noted.
Melatonin Supplement
Other side effect symptoms can include gastrointestinal problems like vomiting, cramping and nausea. High doses of melatonin have been linked to eye disturbances like glaucoma. There is conflicting reports that in some cases melatonin may, in fact, decrease intraocular eye pressure and is sometime used as a treatment for glaucoma.

Lactating and pregnant women should avoid melatonin because of the risk of developmental abnormalities in the fetus. Melatonin is detected in breast milk, so it should be avoided by women who are breasting feeding. Sperm counts have been notably lower in some men who regularly take melatonin, and women taking 50 mg or more have noted irregular menstrual cycles.

Because of the drowsiness side effects, people taking Melatonin should not operate machinery or drive when taking. Melatonin should not be taken with other drugs or alcohol or if a patient has kidney, liver or autoimmune disorders.

How Melatonin Is Sold

Melatonin is available over the counter as a tablet, capsule, transdermal patch, liquid, spray and is now available in some drinks like Dream Water. Melatonin drinks are marketed mainly to young adults, who have difficulty sleeping, but some researchers argue that melatonin should not be added to beverages, because people often drink to quench a thirst and may be ingesting too much of the hormone.

For those who have difficulty swallowing, melatonin spray is popular and available in different strengths.
Tablets and capsules come in different strengths as well and are also available as time released capsules or tablets. The dosage usually starts at 1 mg and goes up to as much as 5 mg. Obviously, if a physician has recommended melatonin for a child, smaller dosages should be given. As far as adult doses go, it usually depends on what works for you. Some people who use melatonin as a sleep aid start with a smaller dosage and increase it as necessary. It is recommended that melatonin be taken 30 to 90 minutes before going to bed.

Adult Dosage Recommendations

The Mayo Clinic has researched melatonin for several conditions. They have found that quick release is more effective for sleep conditions as well as intramuscular injections. Researchers at the Mayo Clinic have also studied melanoma patients who have been treated with melatonin applied directly to the skin. Intranasal solutions of melatonin in 2 milligram doses have also been studied as a treatment for high blood pressure. As with any medication, melatonin dosage should always be discussed with a physician to know how therapeutic melatonin might be on any given medical condition a patient may be suffering from.

Conclusion

Melatonin is produced in the pineal gland of the brain as a hormone. Its synthesis and release are stimulated by suppressed light and darkness, which strongly suggests that melatonin is involved in circadian rhythm and has a diverse affect on various body functions. The levels of melatonin are highest in the blood just before bedtime. Natural melatonin can contain a virus, and synthetic melatonin are used for several medical conditions, but is most proven and tested as a sleep aide. Because melatonin contains antioxide activities, most of its preventive and therapeutic uses are founded on its antioxide properties.

In conclusion, melatonin has been touted as a miracle drug, but more research is needed in many areas to support claims that it can cure everything from cancer to preventing aging. In America, over the counter sales of melatonin continues to thrive, but in in places the the UK, the Department of Health considers it an unlicensed medicine. The question remains, “Is melatonin one of the hottest ‘cure all’ supplements available , or is more detailed research needed to clear up some of the controversy surrounding this miracle drug?